{"id":"W4223607581","doi":"10.21203/rs.3.rs-1525565/v1","title":"Novel Class of Antibiotics Disassembles the Lipopolysaccharide Transport Bridge","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Functional Genomics Center Zurich; Bundesministerium für Bildung und Forschung; Biomedical Advanced Research and Development Authority; National Institute of Allergy and Infectious Diseases; Innosuisse - Schweizerische Agentur für Innovationsförderung; Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator; Wellcome Trust","keywords":"Lipopolysaccharide; Antibiotics; Bridge (graph theory); Class (philosophy); Microbiology; Chemistry; Biology; Computer science; Immunology; Artificial intelligence; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008694547,0.0002138827,0.0002364905,0.0001032837,0.00008988687,0.0002379708,0.0001678474,0.0002735667,0.001310029],"category_scores_gemma":[0.00006844656,0.00005682418,0.0001194169,0.00009974981,0.0001631649,0.0002112684,0.0002498383,0.0003173962,0.0004855229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001611072,"about_ca_system_score_gemma":0.0001447276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008289982,"about_ca_topic_score_gemma":0.00009962955,"domain_scores_codex":[0.999947,0.00000875862,0.000003386104,0.00001492956,0.00001300489,0.00001297802],"domain_scores_gemma":[0.9999616,0.00000508253,0.00001362777,0.000004929164,0.000004774121,0.000009985372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008419235,0.00004233817,0.0001938537,0.0000510099,0.000006573401,0.0001075352,0.00001004931,0.0002718512,0.9919311,0.0008022478,0.0001466937,0.00635241],"study_design_scores_gemma":[0.00006017663,0.0007707164,0.001233116,0.000009259849,0.00001191319,0.0008690254,0.00001681812,0.001671127,0.9767959,0.0004033437,0.01815137,0.000007292077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681717,0.00598607,0.01815552,0.0003488528,0.0002041106,0.00008737296,0.0002701413,0.0001904823,0.006585817],"genre_scores_gemma":[0.9841018,0.001817498,0.009203589,0.0001423676,0.00002986419,0.00003726358,0.0003137309,0.00002179978,0.004331978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310029,"threshold_uncertainty_score":0.004382432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05694959232192599,"score_gpt":0.3730289883216975,"score_spread":0.3160793959997715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}