{"id":"W4223609500","doi":"10.1016/j.eururo.2022.02.023","title":"Pembrolizumab Plus Docetaxel and Prednisone in Patients with Metastatic Castration-resistant Prostate Cancer: Long-term Results from the Phase 1b/2 KEYNOTE-365 Cohort B Study","year":2022,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Western University; Sunnybrook Health Science Centre","funders":"Medical Research Council; National Institute for Health and Care Research","keywords":"Medicine; Docetaxel; Enzalutamide; Prostate cancer; Prednisone; Internal medicine; Oncology; Pembrolizumab; Clinical endpoint; Cohort; Prostate-specific antigen; Cancer; Urology; Surgery; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005922816,0.000226955,0.0003783076,0.0001084117,0.0002938382,0.000039633,0.0001788924,0.00001453223,0.00009746398],"category_scores_gemma":[0.00006485546,0.0001430914,0.00003025666,0.0002654227,0.0001904127,0.00006941125,0.0002100603,0.0004460066,0.000008708373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002109645,"about_ca_system_score_gemma":0.0002598671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008163931,"about_ca_topic_score_gemma":0.0006865589,"domain_scores_codex":[0.9970801,0.0009855952,0.0004217005,0.0006149273,0.0004987772,0.0003988831],"domain_scores_gemma":[0.9989819,0.0001786964,0.0001696203,0.0004554077,0.00008996474,0.0001244208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06244764,0.002966656,0.9217059,0.00002049278,0.0005259125,0.002245533,0.005991935,0.0001894693,0.00009645131,0.000003026987,0.0002844511,0.003522512],"study_design_scores_gemma":[0.08381362,0.007938026,0.9069525,0.00001435761,0.0003294501,0.00001575104,0.000322969,0.00009879997,0.00001010557,0.00000409705,0.0003708575,0.0001294441],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929174,0.001040135,0.000002866585,0.001299278,0.0000958431,0.003211964,0.0008509514,0.00003414104,0.0005474267],"genre_scores_gemma":[0.9977778,0.0001155027,0.00001807337,0.0002754823,0.00005145634,0.0002702005,0.0007647299,0.00004816473,0.000678575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02136599,"threshold_uncertainty_score":0.5835098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02278533837395499,"score_gpt":0.3015875532335694,"score_spread":0.2788022148596145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}