{"id":"W4223617645","doi":"10.1016/j.jbc.2022.101905","title":"Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease","year":2022,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Protein folding; Aggresome; Proteostasis; Hsp90; Chaperone (clinical); Neurodegeneration; Hsp70; Heat shock protein; Foldase; Protein aggregation; Cell biology; Co-chaperone; Biology; Function (biology); Biochemistry; Ubiquitin; GroEL; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008648341,0.0003896878,0.00127734,0.0001088862,0.00007902124,0.00002740775,0.0005762803,0.0004347423,0.0002731527],"category_scores_gemma":[0.00216557,0.0002575347,0.0004230995,0.0002738261,0.0001880264,0.000006664889,0.000610347,0.0009231344,4.004182e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001002813,"about_ca_system_score_gemma":0.0007800597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002863274,"about_ca_topic_score_gemma":7.186073e-7,"domain_scores_codex":[0.9973192,0.0003811753,0.001056776,0.0005125779,0.0003391687,0.000391157],"domain_scores_gemma":[0.9984265,0.000141335,0.0007164369,0.0003202854,0.00009429084,0.0003011633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001224675,0.0006561112,0.0004094604,0.01596228,0.0004263843,0.001096676,0.0000550809,0.00002727117,0.5263506,0.000009791934,0.0001742139,0.4536075],"study_design_scores_gemma":[0.001084065,0.001476118,0.00005206097,0.004223469,0.0001624592,0.0006094556,0.00009352725,0.00001237419,0.08157825,0.00002345281,0.9099889,0.000695915],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1252008,0.8740507,0.00002272038,0.00002718845,0.00004296703,0.0004848512,0.00006603185,0.000003651856,0.0001010568],"genre_scores_gemma":[0.02164361,0.9772832,0.0003519438,0.00001952617,0.000325202,0.0000940291,0.00006852304,0.00003749314,0.0001764765],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9098147,"threshold_uncertainty_score":0.9999877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09987104829897014,"score_gpt":0.3618136859968521,"score_spread":0.261942637697882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}