{"id":"W4223622072","doi":"10.1101/gr.276383.121","title":"H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells","year":2022,"lang":"en","type":"article","venue":"Genome Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; St. Jude Children's Research Hospital","keywords":"Biology; Epigenome; Epigenetics; Chromatin; DNA methylation; Epigenomics; Histone; Genetics; Histone methyltransferase; Cell biology; Methyltransferase; Methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004837,0.0002067193,0.0002275457,0.0002498835,0.0001467514,0.0004791463,0.0003010356,0.0002247481,0.001110615],"category_scores_gemma":[0.00009193312,0.0002630843,0.000229494,0.0002003947,0.0002839085,0.0001788882,0.0003464734,0.0005092596,0.0004731401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004576678,"about_ca_system_score_gemma":0.0002598748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001844584,"about_ca_topic_score_gemma":0.002415422,"domain_scores_codex":[0.9998771,0.000009240626,0.00001355339,0.00003440298,0.00004400262,0.00002164676],"domain_scores_gemma":[0.9999152,0.000008384611,0.00002264942,0.00001451904,0.00001056966,0.00002862186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004046404,0.000004901374,0.0005390615,0.00001343133,0.000003981385,0.00003232378,0.00001727562,0.000141957,0.9979843,0.0001944216,0.00003482169,0.0009931027],"study_design_scores_gemma":[0.00001433213,0.0000708377,0.01764778,0.000005363143,0.00002119045,0.0001402834,0.00005722072,0.002821004,0.9751683,0.0002239054,0.003822185,0.000007804979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902954,0.0009367226,0.005114773,0.00009289026,0.00002283005,0.00001600668,0.0007408814,0.0002197797,0.002560736],"genre_scores_gemma":[0.9939625,0.000470662,0.002113834,0.00007223958,0.000005305954,0.00001264421,0.0005872,0.00004373699,0.002731777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001844584,"threshold_uncertainty_score":0.003715396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04843444932532015,"score_gpt":0.3394072569981126,"score_spread":0.2909728076727924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}