{"id":"W4223623530","doi":"10.1038/s41593-022-01042-4","title":"Genetic variants associated with longitudinal changes in brain structure across the lifespan","year":2022,"lang":"en","type":"review","venue":"Nature Neuroscience","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":252,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Cilag; FP7 Health; FP7 Ideas: European Research Council; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; European Regional Development Fund; Instituto de Salud Carlos III; Comisión Nacional de Investigación Científica y Tecnológica; National Health and Medical Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; Horizon 2020 Framework Programme; Genentech; National Institutes of Health; Max Planck Instituut voor Psycholinguïstiek; Avera Institute for Human Genetics; Heinz Nixdorf Stiftung; Instituto de Investigación Marqués de Valdecilla; UK Dementia Research Institute; Vetenskapsrådet; Neuraxpharm; Fondation Leducq; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; Royal Society; Stichting Vrienden van het Sophia; Diamantina Institute, University of Queensland; Bergens Forskningsstiftelse; University of New South Wales; Radboud Universitair Medisch Centrum; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Stockholms Läns Landsting; Norges Forskningsråd; Universitair Medisch Centrum Groningen; Lundbeckfonden; Universitetet i Oslo; Ministerio de Ciencia e Innovación; Fondation de France; University of Galway; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Helse Vest; Karolinska Institutet; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Gedeon Richter; GGZ Drenthe; National Institute on Aging; Universität Greifswald; GGZ inGeest; Accare; Bundesministerium für Bildung und Forschung; Vrije Universiteit Amsterdam; Universiteit Utrecht; ZonMw; National Natural Science Foundation of China; Universiteit Maastricht; National University of Ireland; Servier; Maastricht Universitair Medisch Centrum; Universiteit Leiden; H. Lundbeck A/S; Institut National de la Santé et de la Recherche Médicale; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Erasmus Medisch Centrum; South African Medical Research Council; Fundação de Amparo à Pesquisa do Estado de São Paulo; AstraZeneca; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; European Commission; Helse Sør-Øst RHF; Max-Planck-Gesellschaft; King's College London; Alzheimer's Society; BioClinica; Fresenius Medical Care North America; Rivierduinen; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; National Alliance for Research on Schizophrenia and Depression; Foundation for the National Institutes of Health; Health Research Board; Fundación Alicia Koplowitz; Mrs Gladys Row Fogo Charitable Trust; Ministry of Cultural Affairs; Fundación Mutua Madrileña; Children's Hospital Foundation; Universiteit Antwerpen; Northern California Institute for Research and Education; National Science Foundation; GGZ Friesland; Biogen; Wellcome Trust; Agence Nationale de la Recherche; Siemens Healthineers; Fondation pour la Recherche Médicale; South London and Maudsley NHS Foundation Trust; Hersenstichting; Centro de Investigación Biomédica en Red de Salud Mental; Radboud Universiteit; Eli Lilly and Company; Leids Universitair Medisch Centrum; Eisai; National Institute on Drug Abuse; Age UK; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Southern California; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Rijksuniversiteit Groningen; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Sunovion; Science Foundation Ireland; U.S. Department of Health and Human Services; Universitetet i Bergen; University of Edinburgh; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; IXICO; Scottish Funding Council; National Healthcare Group; Fédération pour la Recherche sur le Cerveau; Alzheimer's Association","keywords":"Neuroscience; Biology; Psychology; Genetic variants; Evolutionary biology; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007251841,0.0003934944,0.0006812768,0.00007550623,0.0003932512,0.00005849283,0.001090308,0.0007903908,0.00002800728],"category_scores_gemma":[0.002600622,0.0002483023,0.0001388867,0.0009040167,0.00024647,0.000002934034,0.0004563524,0.001445361,0.000001013845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007474225,"about_ca_system_score_gemma":0.0003501268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001317959,"about_ca_topic_score_gemma":0.00172177,"domain_scores_codex":[0.9969102,0.0007917168,0.0003295208,0.0009742886,0.0003398143,0.0006545057],"domain_scores_gemma":[0.9985138,0.0002735607,0.000466803,0.0006262833,0.00004390924,0.00007561309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009442877,0.0005766302,0.05354436,0.001770278,0.0004018691,0.0004868042,0.0006330094,0.001796209,0.002294854,0.000131183,0.023253,0.9150174],"study_design_scores_gemma":[0.0001652926,0.0002738452,0.07325142,0.0001566231,0.00006347209,0.0001397099,0.00001533056,0.00002335393,0.00000366941,0.00002153746,0.9255661,0.0003196041],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01679834,0.9802081,0.00003000492,0.0006173956,0.0009229141,0.0007400289,0.0006094232,0.0000153411,0.00005845948],"genre_scores_gemma":[0.03194129,0.9643645,0.00006696032,0.002453894,0.0002708021,0.0001264413,0.0002188513,0.00005467269,0.0005026299],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9146978,"threshold_uncertainty_score":0.9999969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03074719849215893,"score_gpt":0.3365080485720419,"score_spread":0.305760850079883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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