{"id":"W4223623530","doi":"10.1038/s41593-022-01042-4","title":"Genetic variants associated with longitudinal changes in brain structure across the lifespan","year":2022,"lang":"en","type":"review","venue":"Nature Neuroscience","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":252,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Cilag; FP7 Health; FP7 Ideas: European Research Council; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; European Regional Development Fund; Instituto de Salud Carlos III; Comisión Nacional de Investigación Científica y Tecnológica; National Health and Medical Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; Horizon 2020 Framework Programme; Genentech; National Institutes of Health; Max Planck Instituut voor Psycholinguïstiek; Avera Institute for Human Genetics; Heinz Nixdorf Stiftung; Instituto de Investigación Marqués de Valdecilla; UK Dementia Research Institute; Vetenskapsrådet; Neuraxpharm; Fondation Leducq; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; Royal Society; Stichting Vrienden van het Sophia; Diamantina Institute, University of Queensland; Bergens Forskningsstiftelse; University of New South Wales; Radboud Universitair Medisch Centrum; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Stockholms Läns Landsting; Norges Forskningsråd; Universitair Medisch Centrum Groningen; Lundbeckfonden; Universitetet i Oslo; Ministerio de Ciencia e Innovación; Fondation de France; University of Galway; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Helse Vest; Karolinska Institutet; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Gedeon Richter; GGZ Drenthe; National Institute on Aging; Universität Greifswald; GGZ inGeest; Accare; Bundesministerium für Bildung und Forschung; Vrije Universiteit Amsterdam; Universiteit Utrecht; ZonMw; National Natural Science Foundation of China; Universiteit Maastricht; National University of Ireland; Servier; Maastricht Universitair Medisch Centrum; Universiteit Leiden; H. Lundbeck A/S; Institut National de la Santé et de la Recherche Médicale; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Erasmus Medisch Centrum; South African Medical Research Council; Fundação de Amparo à Pesquisa do Estado de São Paulo; AstraZeneca; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; European Commission; Helse Sør-Øst RHF; Max-Planck-Gesellschaft; King's College London; Alzheimer's Society; BioClinica; Fresenius Medical Care North America; Rivierduinen; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; National Alliance for Research on Schizophrenia and Depression; Foundation for the National Institutes of Health; Health Research Board; Fundación Alicia Koplowitz; Mrs Gladys Row Fogo Charitable Trust; Ministry of Cultural Affairs; Fundación Mutua Madrileña; Children's Hospital Foundation; Universiteit Antwerpen; Northern California Institute for Research and Education; National Science Foundation; GGZ Friesland; Biogen; Wellcome Trust; Agence Nationale de la Recherche; Siemens Healthineers; Fondation pour la Recherche Médicale; South London and Maudsley NHS Foundation Trust; Hersenstichting; Centro de Investigación Biomédica en Red de Salud Mental; Radboud Universiteit; Eli Lilly and Company; Leids Universitair Medisch Centrum; Eisai; National Institute on Drug Abuse; Age UK; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Southern California; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Rijksuniversiteit Groningen; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Sunovion; Science Foundation Ireland; U.S. Department of Health and Human Services; Universitetet i Bergen; University of Edinburgh; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; IXICO; Scottish Funding Council; National Healthcare Group; Fédération pour la Recherche sur le Cerveau; Alzheimer's Association","keywords":"Neuroscience; Biology; Psychology; Genetic variants; Evolutionary biology; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001082814,0.001252563,0.001727876,0.00143773,0.0001565413,0.0009296697,0.0009353047,0.001602468,0.002104411],"category_scores_gemma":[0.002057115,0.00029933,0.0006900185,0.002396515,0.0005716485,0.0006204087,0.00062457,0.001512933,0.0006764366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000615688,"about_ca_system_score_gemma":0.001122893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004329822,"about_ca_topic_score_gemma":0.005730589,"domain_scores_codex":[0.9997371,0.00006227632,0.00004216761,0.00007991026,0.00006113437,0.0000173892],"domain_scores_gemma":[0.9988326,0.0008051281,0.000139678,0.00002565777,0.0001486625,0.00004816312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002659649,0.00005769216,0.004736959,0.008504609,0.001200066,0.000474985,0.00004194109,0.0007894477,0.001024737,0.005913339,0.04185141,0.9351388],"study_design_scores_gemma":[0.0001590012,0.0001946035,0.04647355,0.01521859,0.003519945,0.005757913,0.0001747376,0.0007729292,0.000877388,0.02370226,0.9029998,0.0001492993],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002351495,0.9977903,0.0003286407,0.0008648101,0.0002379881,0.000002264183,0.00008915697,0.000008917163,0.0004427448],"genre_scores_gemma":[0.00141923,0.9967182,0.0003915322,0.0003895606,0.0006056373,0.000006529344,0.0001038506,0.000002237631,0.0003632502],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004329822,"threshold_uncertainty_score":0.008609235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03074719849215893,"score_gpt":0.3365080485720419,"score_spread":0.305760850079883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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