{"id":"W4223645585","doi":"10.1126/sciadv.abm2094","title":"Z-α <sub>1</sub> -antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; Chan Zuckerberg Initiative; Medical Research Council; Pershing Square Sohn Cancer Research Alliance; University of Oxford; National Institutes of Health; Grifols; Wellcome Trust; Imperial College London; Engineering and Physical Sciences Research Council; Cambridge Institute for Medical Research, University of Cambridge; UK Dementia Research Institute; American Cancer Society","keywords":"Calreticulin; Endoplasmic reticulum; Unfolded protein response; Endoplasmic-reticulum-associated protein degradation; Calnexin; ATF6; Chaperone (clinical); Chemistry; Biophysics; Cell biology; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003597145,0.0001445217,0.0001013092,0.0001229674,0.0003051242,0.00006928338,0.0003222181,0.00001973725,0.00001710033],"category_scores_gemma":[0.00007711204,0.0001232401,0.00006709373,0.0005688177,0.0002284075,0.00004396942,0.00008700378,0.0001054869,0.00000409667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003354605,"about_ca_system_score_gemma":0.000236405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009240667,"about_ca_topic_score_gemma":0.00009556006,"domain_scores_codex":[0.9983391,0.0001178718,0.000210141,0.0004912993,0.0004502739,0.0003913698],"domain_scores_gemma":[0.9994766,0.00001873588,0.00006422732,0.0002948846,0.00003736014,0.0001082028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002094528,0.0001188193,0.0001169478,0.00001100437,0.000003487212,0.00005509329,0.0004692113,0.01299834,0.9825071,0.00005064485,0.00002381503,0.003436069],"study_design_scores_gemma":[0.000746539,0.0005168669,0.000297355,0.00001555548,0.000009404743,0.00003439595,0.001396101,0.0004457334,0.9952415,0.0002524185,0.0008427673,0.0002013809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946606,0.0009796612,0.002924071,0.0005860096,0.0001567177,0.0003262781,0.00006722282,0.000009758942,0.0002896397],"genre_scores_gemma":[0.9980274,0.0001142126,0.0002000205,0.00135828,0.0000265367,0.0002148899,0.00003813369,0.00001065031,0.000009810373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01273437,"threshold_uncertainty_score":0.5025584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004022984791622001,"score_gpt":0.2620863496766185,"score_spread":0.2580633648849965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}