{"id":"W4223646367","doi":"10.1021/acs.biomac.2c00117","title":"New Perspectives for Developing Therapeutic Bioconjugates of Metabolite-Depleting Enzymes: Lessons Learned Combating Glutamate Excitotoxicity","year":2022,"lang":"en","type":"review","venue":"Biomacromolecules","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"European Regional Development Fund; Comisión Nacional de Investigación Científica y Tecnológica; Fonds de Recherche du Québec - Santé; Institut National de Recherche et de Sécurité; Norges Forskningsråd; Natural Sciences and Engineering Research Council of Canada; Instituto de Salud Carlos III; Mitacs","keywords":"Excitotoxicity; Glutamate receptor; Neuroscience; Pharmacology; NMDA receptor; Medicine; Chemistry; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000829477,0.0009242746,0.001227738,0.001659032,0.0002292174,0.00108072,0.000891992,0.001653648,0.002730385],"category_scores_gemma":[0.000562549,0.0003190822,0.0005973291,0.00152091,0.0007256991,0.002328389,0.0006766723,0.002928303,0.001418425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007861545,"about_ca_system_score_gemma":0.0008510379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006409202,"about_ca_topic_score_gemma":0.001044492,"domain_scores_codex":[0.9998123,0.00003946586,0.00001947838,0.00003530349,0.00006502626,0.00002843671],"domain_scores_gemma":[0.9998029,0.00009457486,0.00002253832,0.000008960716,0.00004713168,0.00002400007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001070155,0.0001876797,0.0001530681,0.02010216,0.00009428798,0.0004311889,0.0001441067,0.001096467,0.01410604,0.02493774,0.0335333,0.905107],"study_design_scores_gemma":[0.00002467872,0.0001639776,0.00037384,0.001782257,0.00006057313,0.0008113168,0.00005861842,0.0002107681,0.002153146,0.005002885,0.9893365,0.00002140574],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003246119,0.9967434,0.0005911388,0.0006216876,0.0003249145,0.000007044096,0.00001697866,0.00001804851,0.001352232],"genre_scores_gemma":[0.001589844,0.9961592,0.0006256528,0.0004102055,0.0001674815,0.00001705154,0.00003020102,0.000003862203,0.0009963951],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002730385,"threshold_uncertainty_score":0.009134114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1119368884221229,"score_gpt":0.4019907272566845,"score_spread":0.2900538388345616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}