{"id":"W4223646367","doi":"10.1021/acs.biomac.2c00117","title":"New Perspectives for Developing Therapeutic Bioconjugates of Metabolite-Depleting Enzymes: Lessons Learned Combating Glutamate Excitotoxicity","year":2022,"lang":"en","type":"review","venue":"Biomacromolecules","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"European Regional Development Fund; Comisión Nacional de Investigación Científica y Tecnológica; Fonds de Recherche du Québec - Santé; Institut National de Recherche et de Sécurité; Norges Forskningsråd; Natural Sciences and Engineering Research Council of Canada; Instituto de Salud Carlos III; Mitacs","keywords":"Excitotoxicity; Glutamate receptor; Neuroscience; Pharmacology; NMDA receptor; Medicine; Chemistry; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003421588,0.0006335102,0.001220329,0.0002004219,0.0004142284,0.0000898925,0.0005875155,0.0003436443,0.00007505741],"category_scores_gemma":[0.0003409224,0.0005628364,0.001087427,0.0003378139,0.000125316,0.00000719133,0.0004628976,0.0001833595,0.000003707073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006605271,"about_ca_system_score_gemma":0.0007614731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008520984,"about_ca_topic_score_gemma":0.000007650837,"domain_scores_codex":[0.9971077,0.0003870512,0.0007925956,0.0009547659,0.0002434871,0.0005144092],"domain_scores_gemma":[0.9981415,0.0001725286,0.00086325,0.0005696193,0.0001198171,0.0001332372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001078984,0.0002085712,0.000008751446,0.009557373,0.001869367,0.000008385154,0.0002897616,0.000007015844,0.1478812,0.008093314,0.001458011,0.8305104],"study_design_scores_gemma":[0.000497218,0.0003333327,0.00000411567,0.001198368,0.0004830626,0.000032724,0.0004215911,0.000006022283,0.05933182,0.0006092588,0.9362829,0.0007995861],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000310567,0.9902233,0.007340091,0.00004838417,0.0003073079,0.001062541,0.0005361836,0.00005944271,0.0001121823],"genre_scores_gemma":[0.001519901,0.9923119,0.004254214,0.00006299574,0.0003906309,0.0004251512,0.0006832405,0.0001589044,0.0001930915],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9348249,"threshold_uncertainty_score":0.9996823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1119368884221229,"score_gpt":0.4019907272566845,"score_spread":0.2900538388345616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}