{"id":"W4223901815","doi":"10.1101/2022.04.12.487877","title":"Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory intratelencephalic cortical neurons","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Office of Advanced Cyberinfrastructure; Thompson Family Foundation; National Institute on Aging; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Alzheimer's Association; National Science Foundation","keywords":"Neuroscience; Dementia; Cognitive decline; Biology; Disease; Psychology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002114575,0.0002103563,0.0002813857,0.0003830451,0.0002351982,0.0003218091,0.0001556055,0.0001809032,0.001306515],"category_scores_gemma":[0.0002806256,0.0001149307,0.0003426652,0.0002260103,0.0003579118,0.0001811099,0.0003678444,0.0003660261,0.0003204354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001912826,"about_ca_system_score_gemma":0.0002239585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039105,"about_ca_topic_score_gemma":0.001929749,"domain_scores_codex":[0.9998506,0.00000919234,0.000008441069,0.0000751537,0.0000338239,0.00002268566],"domain_scores_gemma":[0.9998111,0.00003094347,0.0000507044,0.00002885938,0.0000457252,0.00003268113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002612903,0.00001805961,0.014167,0.0000862231,0.00004640585,0.00007858074,0.0001324366,0.0001671377,0.9810649,0.0001019836,0.0001551667,0.003720844],"study_design_scores_gemma":[0.00002753379,0.000518273,0.5577953,0.00004607552,0.0002012256,0.001646847,0.0006626727,0.002542463,0.4298155,0.0009040644,0.005795715,0.00004437179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929525,0.0005787169,0.003874689,0.00006040317,0.00001946045,0.00001782817,0.001769213,0.00006083472,0.0006662868],"genre_scores_gemma":[0.9930595,0.0004017386,0.003087972,0.0001283119,0.000009072732,0.00005678488,0.002335336,0.00003623518,0.0008849813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306515,"threshold_uncertainty_score":0.004370689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02731065756195932,"score_gpt":0.2778375153325459,"score_spread":0.2505268577705865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}