{"id":"W4223914468","doi":"10.1172/jci160227","title":"Recalibrating vascular malformations and mechanotransduction by pharmacological intervention","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Vascular Malformations and Hemangiomas","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Fondation Leducq","keywords":"Mechanotransduction; Blood flow; Blood vessel; Hemodynamics; Endothelium; Arteriogenesis; Lymphatic system; Endothelial stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002691418,0.0000715216,0.0002757494,0.0001264869,0.0002037331,0.00002418152,0.00005533069,0.00006378724,0.0003120117],"category_scores_gemma":[0.0003259476,0.00006048556,0.0003035243,0.0002025147,0.00006699529,0.0004481296,0.00003650281,0.0004930746,0.000002356935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004106862,"about_ca_system_score_gemma":0.00006458069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003288891,"about_ca_topic_score_gemma":3.104516e-7,"domain_scores_codex":[0.9979138,0.0003182928,0.001213718,0.00009264651,0.0003732209,0.00008828732],"domain_scores_gemma":[0.9988905,0.00009203266,0.0006353909,0.00007051628,0.0001510349,0.0001605851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002575138,0.006355828,0.1268059,0.001243136,0.004744554,0.0001611482,0.006363858,0.004110497,0.2009844,0.02301223,0.1571681,0.4664752],"study_design_scores_gemma":[0.05468043,0.02350736,0.2746125,0.00110189,0.008247362,0.008222536,0.01050838,0.2179731,0.04191112,0.04554033,0.3120998,0.001595332],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826241,0.0005253977,0.01215001,0.003996085,0.000383669,0.0001883553,0.000004780396,0.00001829654,0.0001093105],"genre_scores_gemma":[0.9919403,0.0002009051,0.006598394,0.0008710513,0.000236068,0.00001276307,0.00005382493,0.000008461954,0.00007827972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4648799,"threshold_uncertainty_score":0.341631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0721099845487768,"score_gpt":0.3786889344411071,"score_spread":0.3065789498923303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}