{"id":"W4223916794","doi":"10.1021/acschemneuro.1c00678","title":"Radiosynthesis and <i>In Vivo</i> Evaluation of Four Positron Emission Tomography Tracer Candidates for Imaging of Melatonin Receptors","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Biomedical Imaging and Bioengineering; Fonds de Recherche du Québec - Santé; Alzheimer Society; Canadian Institutes of Health Research; Réseau en Bio-Imagerie du Quebec; Alzheimer's Association","keywords":"Radioligand; Radiosynthesis; Positron emission tomography; Melatonin; In vivo; Chemistry; Preclinical imaging; Pharmacology; Translocator protein; Binding potential; Agomelatine; Receptor; Internal medicine; Medicine; Biochemistry; Nuclear medicine; Biology; Hippocampus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007303488,0.0006544758,0.0003471028,0.00037096,0.0003636593,0.0004689034,0.0005179563,0.0007554333,0.001957371],"category_scores_gemma":[0.0006713799,0.0003396287,0.0004114041,0.0003848473,0.0003625629,0.0004489374,0.0002058011,0.0005739686,0.0005640752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004425116,"about_ca_system_score_gemma":0.0004550104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001853264,"about_ca_topic_score_gemma":0.001739628,"domain_scores_codex":[0.9997316,0.0001396768,0.00001206651,0.00004202503,0.00002230017,0.00005230697],"domain_scores_gemma":[0.9997892,0.0000577641,0.00004937316,0.00003356963,0.00004295128,0.00002727818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000814012,0.0000941275,0.0003470517,0.0001422038,0.00003987883,0.00009788635,0.00005032961,0.0004953021,0.9932125,0.0005390336,0.0001707487,0.003996956],"study_design_scores_gemma":[0.00006598111,0.001885177,0.0008841816,0.000008496995,0.0001018599,0.0003299159,0.00004113837,0.0009519819,0.9925724,0.0000606687,0.003081264,0.00001687253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9329123,0.01093271,0.04104571,0.0003460831,0.000154796,0.0005055955,0.0006170264,0.0002132834,0.01327249],"genre_scores_gemma":[0.9677233,0.004196522,0.0192492,0.0001309267,0.00003996909,0.0002870988,0.001030718,0.0001381214,0.007204203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001957371,"threshold_uncertainty_score":0.006547987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392827121117118,"score_gpt":0.2643411833247158,"score_spread":0.2404129121135447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}