{"id":"W4223916794","doi":"10.1021/acschemneuro.1c00678","title":"Radiosynthesis and <i>In Vivo</i> Evaluation of Four Positron Emission Tomography Tracer Candidates for Imaging of Melatonin Receptors","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Biomedical Imaging and Bioengineering; Fonds de Recherche du Québec - Santé; Alzheimer Society; Canadian Institutes of Health Research; Réseau en Bio-Imagerie du Quebec; Alzheimer's Association","keywords":"Radioligand; Radiosynthesis; Positron emission tomography; Melatonin; In vivo; Chemistry; Preclinical imaging; Pharmacology; Translocator protein; Binding potential; Agomelatine; Receptor; Internal medicine; Medicine; Biochemistry; Nuclear medicine; Biology; Hippocampus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008303371,0.0001272823,0.000215615,0.0001984828,0.0001347467,0.00001585252,0.0002783297,0.0000303818,0.00002758645],"category_scores_gemma":[0.001162751,0.000127648,0.00007298702,0.0007690412,0.0002856492,0.0001961724,0.0001235372,0.0001467158,1.055385e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005378206,"about_ca_system_score_gemma":0.00008232042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000011421,"about_ca_topic_score_gemma":4.880628e-7,"domain_scores_codex":[0.9980067,0.0001686543,0.0003284762,0.0005385904,0.0006704534,0.0002871162],"domain_scores_gemma":[0.999027,0.0004478098,0.0001846878,0.0002036206,0.00004173193,0.00009515614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007022377,0.00006973271,0.009872035,0.0000194048,4.345024e-7,0.000001621146,0.0001908276,0.00008375052,0.9877636,0.0001457139,0.0001114298,0.001671167],"study_design_scores_gemma":[0.000569818,0.00004677008,0.0017267,0.00002270406,0.00002101301,0.0000406156,0.00004426739,0.0101613,0.9865108,0.0002097762,0.0005240028,0.0001222796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985678,0.0002508275,0.00002395664,0.0002872562,0.0002122238,0.0004146018,0.00005519099,0.00001594555,0.0001722037],"genre_scores_gemma":[0.999527,0.00003570522,0.0001065852,0.0001998182,0.00001164538,0.00007079752,8.822184e-7,0.00001407587,0.00003345343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01007755,"threshold_uncertainty_score":0.5205336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392827121117118,"score_gpt":0.2643411833247158,"score_spread":0.2404129121135447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}