{"id":"W4223921537","doi":"10.1007/s12032-022-01702-2","title":"Telomerase gene therapy: a remission toward cancer","year":2022,"lang":"en","type":"review","venue":"Medical Oncology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Telomerase; Telomere; Cancer; Telomerase reverse transcriptase; Biology; Cancer research; Cancer cell; Telomerase RNA component; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001168625,0.000709413,0.00415277,0.0004225485,0.0001927593,0.00001283064,0.0007055037,0.001444943,0.0572681],"category_scores_gemma":[0.001153618,0.0004886655,0.0008597462,0.0008640128,0.0003792985,0.00003745345,0.0003521926,0.002729441,0.000227149],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001369323,"about_ca_system_score_gemma":0.00957722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002818562,"about_ca_topic_score_gemma":0.00002917157,"domain_scores_codex":[0.9943714,0.0008189984,0.001318802,0.001058531,0.001582448,0.0008498233],"domain_scores_gemma":[0.9963431,0.0009653961,0.000510591,0.0007734771,0.00007682778,0.001330621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001727842,0.0005833858,0.00002316712,0.00444948,0.0003132132,0.004069861,0.0001635199,2.76218e-8,0.000007107065,0.0000146425,0.02154943,0.9686534],"study_design_scores_gemma":[0.001593688,0.001124534,0.00001065283,0.003712501,0.0007030059,0.002028733,0.00003907292,0.00000654336,0.000009424065,0.00000908842,0.9903008,0.0004619311],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007484925,0.9896352,0.00001723026,0.003191028,0.002417793,0.001274208,0.0000589448,0.000203581,0.003127173],"genre_scores_gemma":[0.000009363504,0.9875541,0.0002667214,0.005430209,0.00214184,0.000931926,0.0004463473,0.0001399069,0.003079551],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9687514,"threshold_uncertainty_score":0.9998514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1921261202198647,"score_gpt":0.4605155089703968,"score_spread":0.2683893887505321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}