{"id":"W4223923513","doi":"10.3390/vaccines10040607","title":"Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change","year":2022,"lang":"en","type":"review","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North; Université de Sherbrooke","funders":"Agencia Estatal de Investigación; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Ikerbasque, Basque Foundation for Science; Basque Center for Applied Mathematics; Eusko Jaurlaritza; Université de Sherbrooke","keywords":"Immunosenescence; Ageing; Immune system; Immunology; Disease; Medicine; Influenza vaccine; Healthy ageing; Vaccine efficacy; Vaccination; Gerontology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118144,0.0006909661,0.001584727,0.00126362,0.0002809072,0.001362263,0.0008623053,0.002292475,0.002238883],"category_scores_gemma":[0.002122994,0.0002246816,0.000694192,0.0009057545,0.0008168556,0.002345751,0.0006945546,0.003069469,0.001022521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005710931,"about_ca_system_score_gemma":0.0009308121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000825868,"about_ca_topic_score_gemma":0.00105734,"domain_scores_codex":[0.9996494,0.000100369,0.00006430738,0.00006094635,0.00009653829,0.00002834182],"domain_scores_gemma":[0.9990535,0.0005995346,0.00009849574,0.00002509868,0.0001815007,0.00004178391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000143662,0.00006970273,0.0003629757,0.01825403,0.0001826563,0.0001783675,0.0001538585,0.0002141251,0.0008959466,0.007337277,0.05414442,0.9180629],"study_design_scores_gemma":[0.00003562156,0.0002155432,0.001741525,0.01136576,0.0002087515,0.001772124,0.0001772438,0.0001134438,0.000358756,0.006522492,0.9774549,0.00003383196],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008453176,0.9977105,0.00005956532,0.001366277,0.0004677989,0.000002002139,0.00001053239,0.000004686203,0.0002940451],"genre_scores_gemma":[0.0009070694,0.9964966,0.0001467722,0.001224007,0.0007710094,0.000008014671,0.00001899943,0.000001965281,0.0004257224],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002292475,"threshold_uncertainty_score":0.007489741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08399887800049319,"score_gpt":0.3832696092796385,"score_spread":0.2992707312791454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}