{"id":"W4223923513","doi":"10.3390/vaccines10040607","title":"Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change","year":2022,"lang":"en","type":"review","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North; Université de Sherbrooke","funders":"Agencia Estatal de Investigación; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Ikerbasque, Basque Foundation for Science; Basque Center for Applied Mathematics; Eusko Jaurlaritza; Université de Sherbrooke","keywords":"Immunosenescence; Ageing; Immune system; Immunology; Disease; Medicine; Influenza vaccine; Healthy ageing; Vaccine efficacy; Vaccination; Gerontology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005073893,0.0006099055,0.002046682,0.001163466,0.0001004594,0.00006001892,0.0004693507,0.0002261216,0.0001074955],"category_scores_gemma":[0.0005348658,0.0004520504,0.0002476095,0.002587877,0.0000150297,0.00008890251,0.0005564741,0.0007403407,0.0001244215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002702041,"about_ca_system_score_gemma":0.0003191892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004992823,"about_ca_topic_score_gemma":0.0001188211,"domain_scores_codex":[0.9967981,0.0001934137,0.0007590958,0.0009984642,0.0005234755,0.0007274284],"domain_scores_gemma":[0.9985041,0.0002738552,0.000175549,0.000834902,0.0001049255,0.0001066834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001962267,0.0004874135,0.001518304,0.01970161,0.00008805894,0.0003742432,0.0007301111,2.07717e-8,0.00009441194,0.000007217352,0.001258232,0.9755442],"study_design_scores_gemma":[0.001579804,0.0004222478,0.002819552,0.007022291,0.0002215516,0.0003138104,0.0001162057,0.000008451432,0.00003938692,0.000003029252,0.9869977,0.0004559761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008396189,0.9865975,0.000003653977,0.0002749625,0.0003558472,0.004017699,0.0000244417,0.00009351766,0.000236179],"genre_scores_gemma":[0.0003496252,0.9871708,0.00003269722,0.009055109,0.0006020769,0.002481679,0.00003332984,0.0001302969,0.0001444335],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9857395,"threshold_uncertainty_score":0.9997931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08399887800049319,"score_gpt":0.3832696092796385,"score_spread":0.2992707312791454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}