{"id":"W4223923740","doi":"10.2174/1389201023666220413092507","title":"FLG Gene Mutation Up-regulates the Abnormal Tumor Immune Response and Promotes the Progression of Prostate Cancer","year":2022,"lang":"en","type":"article","venue":"Current Pharmaceutical Biotechnology","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Prostate cancer; Immune system; Immunotherapy; Cancer research; Mutation; PTEN; Cancer; Immune checkpoint; Biology; Somatic cell; Context (archaeology); Germline mutation; Gene; Immunology; Genetics; PI3K/AKT/mTOR pathway; Apoptosis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007293005,0.0001616947,0.000248267,0.0001035556,0.000354783,0.00001352241,0.0002250113,0.00006539661,0.00019083],"category_scores_gemma":[0.00008800838,0.00008854875,0.0000747629,0.0004568749,0.0007770173,0.00003959725,0.0004074093,0.0007503139,0.000002060725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005989568,"about_ca_system_score_gemma":0.0001318066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009427833,"about_ca_topic_score_gemma":5.951254e-7,"domain_scores_codex":[0.9984747,0.0002581636,0.0003455942,0.0002973089,0.0003102768,0.0003139554],"domain_scores_gemma":[0.9992963,0.0001213152,0.0001664435,0.0002814984,0.00007506859,0.000059386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004309064,0.0003776036,0.004234615,0.0001921029,0.00010629,0.00001329006,0.0006402946,0.00001075924,0.4581448,0.0005840868,0.0002900792,0.531097],"study_design_scores_gemma":[0.001628141,0.000834247,0.009438817,0.00008235909,0.000217503,0.0002198591,0.0004137414,0.002427354,0.9270169,0.00007779411,0.05751832,0.0001249185],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.924437,0.03109778,0.000006859428,0.04273211,0.00037286,0.001217107,0.00004750985,0.00008402737,0.000004701466],"genre_scores_gemma":[0.9970397,0.001772439,0.00005641423,0.0001892316,0.00004257483,0.0008307268,0.00001589618,0.00001806154,0.00003495062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5309721,"threshold_uncertainty_score":0.3610913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0340736321823451,"score_gpt":0.366382775505434,"score_spread":0.3323091433230889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}