{"id":"W4223930597","doi":"10.1101/2022.04.11.22273748","title":"Cross-tissue meta-analysis of blood and brain epigenome-wide association studies in Alzheimer’s disease","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; H. Lundbeck A/S; Illinois Department of Public Health; Rush University; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Translational Genomics Research Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"DNA methylation; Epigenome; Biomarker; TREM2; Biology; Methylation; Disease; Oncology; Bioinformatics; Medicine; Gene; Internal medicine; Immune system; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01479829,0.00179245,0.004332837,0.002773487,0.0007411848,0.002526239,0.001204976,0.001055794,0.003559269],"category_scores_gemma":[0.02015327,0.0008245379,0.01855467,0.004433662,0.0004576661,0.0008374769,0.001653093,0.001770674,0.0003822128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005576294,"about_ca_system_score_gemma":0.0007378039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004780197,"about_ca_topic_score_gemma":0.006067688,"domain_scores_codex":[0.9890857,0.006658413,0.0007369569,0.002564601,0.0005665804,0.0003877519],"domain_scores_gemma":[0.9838368,0.01124449,0.001047046,0.002814885,0.0007159233,0.0003408325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004733603,0.00003905345,0.1668229,0.0049161,0.7996913,0.0004355969,0.0001019406,0.003925964,0.003823463,0.0005777688,0.002471972,0.01246038],"study_design_scores_gemma":[0.0008671898,0.000504695,0.1769608,0.0009372373,0.8007734,0.0006067599,0.0001382242,0.007106279,0.002425323,0.003048014,0.006564947,0.000067107],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5492688,0.3659524,0.05297999,0.003213204,0.001452077,0.0002184387,0.02333909,0.001064498,0.002511509],"genre_scores_gemma":[0.9778624,0.01018104,0.005802962,0.0005728135,0.0002429464,0.0001346533,0.004436893,0.000183722,0.0005826116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01479829,"threshold_uncertainty_score":0.07826179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08657331075371995,"score_gpt":0.3772657741219555,"score_spread":0.2906924633682356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}