{"id":"W4223933379","doi":"10.3390/biomedicines10040890","title":"Interleukin-10 Mitigates Doxorubicin-Induced Endoplasmic Reticulum Stress as Well as Cardiomyopathy","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Heart and Stroke Foundation of Canada","keywords":"Endoplasmic reticulum; Unfolded protein response; Protein disulfide-isomerase; Cell biology; Downregulation and upregulation; Kinase; Apoptosis; ASK1; Doxorubicin; p38 mitogen-activated protein kinases; Chemistry; Protein kinase A; Biology; Internal medicine; Biochemistry; Medicine; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001912658,0.0003682434,0.0003562794,0.0001756638,0.0002930904,0.0000376953,0.0004920113,0.000118902,0.001755299],"category_scores_gemma":[0.0001664598,0.0003297112,0.0002426419,0.0002744483,0.0002220531,0.000006740595,0.0004878627,0.0001949997,0.0002537983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004012004,"about_ca_system_score_gemma":0.0002058462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004220979,"about_ca_topic_score_gemma":0.00002115776,"domain_scores_codex":[0.9976776,0.0001632078,0.000401331,0.0007336037,0.0005033592,0.0005209145],"domain_scores_gemma":[0.9986651,0.00003678921,0.0001650911,0.0006848869,0.0001130284,0.0003351128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005264065,0.0002969127,0.009519051,0.000105333,0.0002141274,0.0004414285,0.0001910584,0.00005109456,0.9325873,0.0001661206,0.05473634,0.001164851],"study_design_scores_gemma":[0.001996452,0.001771073,0.0008564264,0.00005796458,0.0001297287,0.0003589764,0.00272514,0.00005375835,0.7026103,0.0001548832,0.28877,0.0005153685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759026,0.002245457,0.00001015312,0.0006823167,0.001153813,0.0003500427,0.0001636889,0.00005987717,0.01943206],"genre_scores_gemma":[0.9892946,0.0002220959,0.00003882906,0.0009323401,0.0007367315,0.0001823131,0.0007695233,0.00005666017,0.007766893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2340336,"threshold_uncertainty_score":0.9999155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005480774416401284,"score_gpt":0.2392072706227079,"score_spread":0.2337264962063066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}