{"id":"W4223954854","doi":"10.1056/nejmoa2116634","title":"Mitapivat versus Placebo for Pyruvate Kinase Deficiency","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Agios Pharmaceuticals","keywords":"Pyruvate kinase; Pyruvate kinase deficiency; Placebo; Chemistry; Medicine; Biochemistry; Enzyme; Glycolysis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001559918,0.0009106254,0.002387621,0.0004632626,0.0003011364,0.0007242951,0.0005920395,0.001092468,0.006394456],"category_scores_gemma":[0.001835524,0.0004465222,0.001275363,0.0003361055,0.0007450655,0.0006483056,0.0003445469,0.002225385,0.0005430692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004156798,"about_ca_system_score_gemma":0.0006945258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001920542,"about_ca_topic_score_gemma":0.0003842269,"domain_scores_codex":[0.9994158,0.0003025022,0.00005949292,0.0001012464,0.00004778485,0.00007332089],"domain_scores_gemma":[0.9989508,0.0004262226,0.0003321086,0.00004473868,0.000043535,0.0002025076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9464793,0.004777884,0.000651566,0.001366613,0.0009476152,0.00006611315,0.00004448284,0.0003358548,0.005715678,0.0001392242,0.0006842414,0.03879149],"study_design_scores_gemma":[0.7831483,0.2089762,0.003094131,0.0001379147,0.0008092407,0.00014005,0.00002924009,0.0007088716,0.001708674,0.000182989,0.001047197,0.00001714625],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742078,0.0192608,0.0005882271,0.0007898667,0.0008104407,0.001667119,0.0004630916,0.0001505255,0.00206217],"genre_scores_gemma":[0.9897032,0.005043391,0.0008703023,0.0006697359,0.0004706369,0.001793021,0.0002634305,0.00001126703,0.00117504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006394456,"threshold_uncertainty_score":0.02139157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04130897264640187,"score_gpt":0.2994987245663949,"score_spread":0.258189751919993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}