{"id":"W4223967404","doi":"10.1007/s13555-022-00721-1","title":"Comparative Efficacy of Targeted Systemic Therapies for Moderate to Severe Atopic Dermatitis without Topical Corticosteroids: Systematic Review and Network Meta-analysis","year":2022,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of British Columbia","funders":"Janssen Pharmaceuticals; Sanofi Genzyme; LEO Pharma; Bausch Health; Kyowa Hakko Kirin; Lundbeckfonden; Glenmark Pharmaceuticals; Dermira; UCB Pharma; Regeneron Pharmaceuticals; Celgene; Genentech; Valeant Pharmaceuticals International; Kiniksa Pharmaceuticals; AbbVie; Sanofi; Amgen; Pfizer; Galderma; Ortho Dermatologics; Eli Lilly and Company; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Eczema Area and Severity Index; Atopic dermatitis; Medicine; Clinical endpoint; Placebo; Internal medicine; Meta-analysis; Randomized controlled trial; Dermatology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02785229,0.002729753,0.01656545,0.00707664,0.0004658505,0.003102468,0.002179008,0.001814583,0.004007247],"category_scores_gemma":[0.05803579,0.001338645,0.0376459,0.006495536,0.000761316,0.001922726,0.001506392,0.001585213,0.0003153693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002767501,"about_ca_system_score_gemma":0.003116562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006432584,"about_ca_topic_score_gemma":0.01162209,"domain_scores_codex":[0.976785,0.01529368,0.004038384,0.001892337,0.001643433,0.0003470844],"domain_scores_gemma":[0.9627622,0.03049606,0.003902968,0.001089955,0.001494792,0.0002539885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001973032,0.00001716911,0.003091256,0.16389,0.8219301,0.00005508555,0.00004450366,0.0008409173,0.0001089046,0.0001690878,0.0004199735,0.00745989],"study_design_scores_gemma":[0.0007565049,0.0001532089,0.002200271,0.01279203,0.9821272,0.00005109777,0.0000227122,0.0003447467,0.00006439687,0.0003792807,0.001091068,0.00001745899],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.007219339,0.9878128,0.001900282,0.0003715215,0.0002217442,0.0006332742,0.001281981,0.00005139956,0.0005076615],"genre_scores_gemma":[0.3962878,0.5879386,0.007520799,0.001535667,0.0003969813,0.003472162,0.002191288,0.00007484219,0.0005819406],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02785229,"threshold_uncertainty_score":0.1472987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05027359687013831,"score_gpt":0.3224130559871784,"score_spread":0.2721394591170401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}