{"id":"W4223967404","doi":"10.1007/s13555-022-00721-1","title":"Comparative Efficacy of Targeted Systemic Therapies for Moderate to Severe Atopic Dermatitis without Topical Corticosteroids: Systematic Review and Network Meta-analysis","year":2022,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of British Columbia","funders":"Janssen Pharmaceuticals; Sanofi Genzyme; LEO Pharma; Bausch Health; Kyowa Hakko Kirin; Lundbeckfonden; Glenmark Pharmaceuticals; Dermira; UCB Pharma; Regeneron Pharmaceuticals; Celgene; Genentech; Valeant Pharmaceuticals International; Kiniksa Pharmaceuticals; AbbVie; Sanofi; Amgen; Pfizer; Galderma; Ortho Dermatologics; Eli Lilly and Company; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Eczema Area and Severity Index; Atopic dermatitis; Medicine; Clinical endpoint; Placebo; Internal medicine; Meta-analysis; Randomized controlled trial; Dermatology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001811622,0.0002177495,0.003116877,0.0001139358,0.0002493214,0.00001096629,0.0001010807,0.00007210387,0.0001241729],"category_scores_gemma":[0.00003607844,0.0001569536,0.0003784247,0.0002680293,0.0001176628,0.00005194417,0.00004845078,0.0001288545,0.00000156216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009807009,"about_ca_system_score_gemma":0.00003649512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003915331,"about_ca_topic_score_gemma":0.000003352781,"domain_scores_codex":[0.9980381,0.0006778176,0.000643303,0.0002877162,0.0001287924,0.0002243339],"domain_scores_gemma":[0.9987581,0.0004712392,0.0002489784,0.000310019,0.0000986532,0.0001129817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00277283,0.001188022,0.1675305,0.1977164,0.5984519,0.0003226667,0.01370557,0.0007108944,0.000146552,0.006565626,0.01069868,0.0001905041],"study_design_scores_gemma":[0.0186377,0.001410225,0.08125345,0.004516075,0.8533237,0.0241532,0.002973008,0.005607159,0.0008116773,0.003402835,0.002042799,0.001868151],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4454933,0.5463031,0.001104261,0.003635749,0.00005034516,0.003271764,0.00006668202,0.0000407591,0.00003403772],"genre_scores_gemma":[0.9859652,0.00389168,0.0002438418,0.008702725,0.000007467306,0.001047505,0.00005683094,0.00001122775,0.00007355445],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5424114,"threshold_uncertainty_score":0.640038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05027359687013831,"score_gpt":0.3224130559871784,"score_spread":0.2721394591170401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}