{"id":"W4223971949","doi":"10.1002/mus.27558","title":"Randomized phase 2 study of<scp>ACE</scp>‐083, a<scp>muscle‐promoting</scp>agent, in facioscapulohumeral muscular dystrophy","year":2022,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Calgary; Western University","funders":"Acceleron; National Center for Advancing Translational Sciences; American Academy of Neurology; Muscular Dystrophy Association","keywords":"Facioscapulohumeral muscular dystrophy; Medicine; Biceps; Tolerability; Muscular dystrophy; Internal medicine; Placebo; Adverse effect; Confidence interval; Cardiology; Physical therapy; Urology; Physical medicine and rehabilitation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001285326,0.0005344527,0.001021239,0.0002500296,0.0003808126,0.00003523452,0.0007440704,0.0002382833,0.00008081515],"category_scores_gemma":[0.0007284572,0.000545359,0.0006008096,0.0005140389,0.0002374798,0.00001971924,0.0007207066,0.0005490165,0.00001403209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004650122,"about_ca_system_score_gemma":0.0001193296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004523319,"about_ca_topic_score_gemma":0.00008737358,"domain_scores_codex":[0.9950442,0.001579643,0.0009505042,0.001109536,0.0004869695,0.0008291237],"domain_scores_gemma":[0.9980065,0.0002260458,0.0004833222,0.0009732901,0.0001093419,0.0002015606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.005101195,0.0113363,0.003636623,0.0002047813,0.0009967351,0.000213246,0.01021618,0.005461803,0.9522121,0.000189621,0.005220423,0.005210961],"study_design_scores_gemma":[0.7752345,0.0129013,0.0307052,0.00007492038,0.0008617921,0.00004439185,0.03637668,0.003479973,0.0559241,0.001534496,0.08183871,0.001023914],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950112,0.001466632,0.0001408789,0.00004893376,0.0004582811,0.001753141,0.000113336,0.00005082926,0.0009568023],"genre_scores_gemma":[0.9976791,0.00008062011,0.00008857043,0.0002490559,0.0001741808,0.0006909133,0.0004647991,0.00008155614,0.0004912713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.896288,"threshold_uncertainty_score":0.9996998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259442703236117,"score_gpt":0.2626308489267194,"score_spread":0.2500364218943582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}