{"id":"W4223971949","doi":"10.1002/mus.27558","title":"Randomized phase 2 study of<scp>ACE</scp>‐083, a<scp>muscle‐promoting</scp>agent, in facioscapulohumeral muscular dystrophy","year":2022,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Calgary; Western University","funders":"Acceleron; National Center for Advancing Translational Sciences; American Academy of Neurology; Muscular Dystrophy Association","keywords":"Facioscapulohumeral muscular dystrophy; Medicine; Biceps; Tolerability; Muscular dystrophy; Internal medicine; Placebo; Adverse effect; Confidence interval; Cardiology; Physical therapy; Urology; Physical medicine and rehabilitation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001793356,0.001531361,0.002238124,0.0004337351,0.0004207701,0.0008135298,0.0007901908,0.001486389,0.006646557],"category_scores_gemma":[0.001333594,0.0007454224,0.0008777028,0.0003002503,0.0008181944,0.0007855428,0.0003002964,0.002224557,0.00101159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006513523,"about_ca_system_score_gemma":0.001618268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008996136,"about_ca_topic_score_gemma":0.002569031,"domain_scores_codex":[0.9994772,0.0002754906,0.00002764121,0.0000874599,0.00004559655,0.00008654422],"domain_scores_gemma":[0.9992067,0.000219505,0.0001625521,0.00007585522,0.00007428228,0.000261055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9528094,0.02350662,0.0006135285,0.0003194832,0.0005071724,0.0000489236,0.00005534119,0.0003501098,0.007619327,0.0001058232,0.0009085325,0.01315579],"study_design_scores_gemma":[0.9001029,0.09739628,0.001047554,0.00001145435,0.0001515034,0.00002467486,0.00001116192,0.0002763821,0.0005003213,0.00006352994,0.0004061973,0.000008036104],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849851,0.001701196,0.0008923319,0.0004234633,0.000330999,0.008487583,0.001403929,0.0001667983,0.001608528],"genre_scores_gemma":[0.9773135,0.001595273,0.002983785,0.001114229,0.0004015017,0.01148241,0.001305372,0.00004180385,0.003762205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006646557,"threshold_uncertainty_score":0.02223492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259442703236117,"score_gpt":0.2626308489267194,"score_spread":0.2500364218943582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}