{"id":"W4223972675","doi":"10.3899/jrheum.210912","title":"Secukinumab in United States Biologic-Naïve Patients With Psoriatic Arthritis: Results From the Randomized, Placebo-Controlled CHOICE Study","year":2022,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Pennsylvania; Novartis Pharmaceuticals Corporation; Celgene; Johns Hopkins University; Amgen; Pfizer; Eli Lilly and Company","keywords":"Medicine; Placebo; Psoriatic arthritis; Internal medicine; Secukinumab; Dactylitis; Adverse effect; Population; Psoriasis; Rheumatology; Gastroenterology; Odds ratio; Enthesitis; Randomized controlled trial; Arthritis; Surgery; Dermatology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004792612,0.001030242,0.0024576,0.0004406082,0.0003276424,0.0007167626,0.0005893874,0.001454256,0.005952341],"category_scores_gemma":[0.004529893,0.0005640983,0.002053785,0.00051645,0.001169942,0.0008412544,0.0003209249,0.001591582,0.0004751837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005749319,"about_ca_system_score_gemma":0.0009812929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006337019,"about_ca_topic_score_gemma":0.001273335,"domain_scores_codex":[0.997485,0.001895588,0.000168555,0.0001752932,0.000170711,0.0001046814],"domain_scores_gemma":[0.9967549,0.001363711,0.0008933587,0.0002274503,0.0002061465,0.0005544502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9856895,0.003131584,0.0008644102,0.0004504613,0.000849047,0.00002012914,0.00002508281,0.0001390066,0.001412097,0.00003910204,0.0002515611,0.007127958],"study_design_scores_gemma":[0.9470772,0.04936568,0.002043236,0.00003006383,0.0006065089,0.00002681517,0.00001072403,0.0002325078,0.0003075898,0.00004164089,0.0002499455,0.000008098303],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887345,0.00738621,0.0004554954,0.000504236,0.0002781314,0.001359122,0.0005484381,0.00004902924,0.0006847421],"genre_scores_gemma":[0.9918067,0.003362747,0.001025516,0.0006826108,0.0003687536,0.00148202,0.0005277589,0.00001229782,0.0007316119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005952341,"threshold_uncertainty_score":0.0253461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008509692250932935,"score_gpt":0.2368335876454632,"score_spread":0.2283238953945303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}