{"id":"W4223989341","doi":"10.1002/eji.202149774","title":"Human cDC1s display constitutive activation of the UPR sensor IRE1","year":2022,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; Universidad de Chile; Sunnybrook Research Institute; Howard Hughes Medical Institute","keywords":"Biology; Cell biology; RNase P; Signal transduction; Function (biology); Gene; RNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002490749,0.00008033506,0.0001210183,0.00003820422,0.0001759609,0.000005542143,0.0003131026,0.00001659471,0.00006390495],"category_scores_gemma":[0.0001151214,0.00005808884,0.0001363874,0.00006016831,0.0002456346,0.00000348368,0.0002457731,0.000196877,0.000001765146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001546878,"about_ca_system_score_gemma":0.0000753673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003184405,"about_ca_topic_score_gemma":3.923919e-7,"domain_scores_codex":[0.9987941,0.0005886049,0.0002981941,0.00009735322,0.0001135409,0.0001082054],"domain_scores_gemma":[0.9992117,0.00001265115,0.0004395226,0.000214305,0.0000936561,0.00002820583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002100646,0.0001083803,0.003080875,0.000005283449,0.000153841,0.00003755259,0.0001078124,0.0005563125,0.9927853,0.0008876668,0.001353664,0.0007132001],"study_design_scores_gemma":[0.004528379,0.00278429,0.1528554,0.00007494306,0.0001456145,0.001066379,0.002378589,0.00001145539,0.7321908,0.0001258087,0.1034941,0.0003441573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934333,0.0004478589,0.0001623571,0.0002112504,0.0003188631,0.00005743479,0.00002040164,0.000001754535,0.005346789],"genre_scores_gemma":[0.9993358,0.00003238549,0.00005057288,0.0001412043,0.00008347533,0.000001069827,0.000008853302,0.00001105768,0.0003355369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2605945,"threshold_uncertainty_score":0.2368794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007568143455153217,"score_gpt":0.2249437988080061,"score_spread":0.2173756553528529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}