{"id":"W4223989341","doi":"10.1002/eji.202149774","title":"Human cDC1s display constitutive activation of the UPR sensor IRE1","year":2022,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; Universidad de Chile; Sunnybrook Research Institute; Howard Hughes Medical Institute","keywords":"Biology; Cell biology; RNase P; Signal transduction; Function (biology); Gene; RNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030466,0.0002268575,0.0001805354,0.0002087939,0.0001912051,0.0002997618,0.00009865353,0.0002196516,0.001487141],"category_scores_gemma":[0.0001205377,0.00008430563,0.0001861152,0.0002271204,0.0001521134,0.00008330572,0.0001483523,0.0003126742,0.0006515954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002233288,"about_ca_system_score_gemma":0.0001405144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004935424,"about_ca_topic_score_gemma":0.0004820234,"domain_scores_codex":[0.9998903,0.00001465551,0.00001208356,0.00002424104,0.00002876689,0.0000300438],"domain_scores_gemma":[0.9999071,0.00001501298,0.0000211965,0.00002253612,0.00001121717,0.00002290243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001493768,0.0000232036,0.0004740586,0.00001958512,0.000004113619,0.0001313111,0.00002037783,0.0000643833,0.9980141,0.0001243551,0.00008804301,0.000886931],"study_design_scores_gemma":[0.00002128085,0.0002707807,0.01313244,0.000007543792,0.00001448733,0.001770263,0.0000753971,0.00100096,0.9752553,0.00011278,0.008329438,0.000009204037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948816,0.001145303,0.00116975,0.0001030622,0.0000248448,0.00001754329,0.001307503,0.00004701594,0.001303378],"genre_scores_gemma":[0.9940223,0.0005504108,0.0009801555,0.00004692362,0.000008624686,0.00002497321,0.002582285,0.00001425847,0.001769929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487141,"threshold_uncertainty_score":0.004974961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007568143455153217,"score_gpt":0.2249437988080061,"score_spread":0.2173756553528529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}