{"id":"W4224031231","doi":"10.1101/2022.04.12.488081","title":"EstG is a novel esterase required for cell envelope integrity","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brookhaven National Laboratory; Basic Energy Sciences; National Institute of General Medical Sciences; Knut och Alice Wallenbergs Stiftelse; National Institutes of Health; Vetenskapsrådet; Biological and Environmental Research; Kempe Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; U.S. Department of Energy","keywords":"Caulobacter crescentus; Periplasmic space; Cell envelope; Enzyme; Biology; Cell wall; Biochemistry; Cell; Cell biology; Esterase; Bacterial cell structure; Bacteria; Cell cycle; Genetics; Escherichia coli; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117311,0.0004947961,0.0002484503,0.0001999008,0.0001110023,0.0003537335,0.0002045252,0.0003695181,0.0006384611],"category_scores_gemma":[0.000114388,0.0001046021,0.0003268453,0.000204694,0.0002516734,0.0001557508,0.0002060628,0.0003202607,0.0003354852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003585016,"about_ca_system_score_gemma":0.0002092784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005025484,"about_ca_topic_score_gemma":0.000366239,"domain_scores_codex":[0.9999188,0.000008678446,0.000007398728,0.00002603711,0.00002131326,0.00001768331],"domain_scores_gemma":[0.9998806,0.00001320378,0.00003731625,0.00001745167,0.00001515526,0.00003633961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008842791,0.00001677264,0.0007114241,0.00002832967,0.00000669673,0.0002897477,0.000008769345,0.00006444246,0.996982,0.00009987586,0.00006343297,0.001640143],"study_design_scores_gemma":[0.0000355654,0.0001301541,0.01296215,0.000009612026,0.00002050636,0.001575045,0.00003920564,0.001295261,0.9790384,0.0001739422,0.004711425,0.000008739871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904322,0.001843963,0.00578336,0.0001690376,0.0000531839,0.00002904673,0.0007913446,0.0001699257,0.0007280301],"genre_scores_gemma":[0.99128,0.0003913242,0.003987567,0.00009363596,0.00001296089,0.00001249448,0.002279831,0.00003116201,0.001911034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006384611,"threshold_uncertainty_score":0.002601147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093641472329291,"score_gpt":0.2428850741882224,"score_spread":0.2219486594649295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}