{"id":"W4224031231","doi":"10.1101/2022.04.12.488081","title":"EstG is a novel esterase required for cell envelope integrity","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brookhaven National Laboratory; Basic Energy Sciences; National Institute of General Medical Sciences; Knut och Alice Wallenbergs Stiftelse; National Institutes of Health; Vetenskapsrådet; Biological and Environmental Research; Kempe Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; U.S. Department of Energy","keywords":"Caulobacter crescentus; Periplasmic space; Cell envelope; Enzyme; Biology; Cell wall; Biochemistry; Cell; Cell biology; Esterase; Bacterial cell structure; Bacteria; Cell cycle; Genetics; Escherichia coli; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004453882,0.0004483666,0.0003381456,0.0001243862,0.0002110312,0.0001323121,0.0005025487,0.0005206161,0.00009377868],"category_scores_gemma":[0.0001897879,0.0005254141,0.0002064067,0.0001964264,0.00006523071,0.00001253393,0.0006632578,0.0005332252,0.00001360013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001104134,"about_ca_system_score_gemma":0.0005813667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001325794,"about_ca_topic_score_gemma":0.000001013007,"domain_scores_codex":[0.9976419,0.00007578208,0.0004529417,0.001218531,0.0002254557,0.0003854338],"domain_scores_gemma":[0.9977865,0.00001203953,0.0003993032,0.001206283,0.0004286729,0.000167238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009832558,0.0002550023,0.001274055,0.0002448638,0.0000736443,0.000001867198,0.00001205159,0.00001566793,0.9945655,0.00006986842,0.003387691,0.000001412445],"study_design_scores_gemma":[0.0006314571,0.0001074383,0.004892163,0.00003002699,0.00005794011,1.916445e-8,0.00000447913,0.00007958987,0.8127613,8.602543e-7,0.1808772,0.0005575333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733015,0.0008201024,0.01996635,0.0009105664,0.002225006,0.001166324,0.001456125,0.0001396341,0.00001433415],"genre_scores_gemma":[0.985683,0.0003496094,0.01076163,0.001185076,0.001010033,0.0006791943,0.00003143933,0.0001478593,0.0001521559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1818042,"threshold_uncertainty_score":0.9997197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093641472329291,"score_gpt":0.2428850741882224,"score_spread":0.2219486594649295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}