{"id":"W4224050212","doi":"10.1126/scitranslmed.abn2231","title":"Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice","year":2022,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Rosetrees Trust; National Cancer Institute; National Institute for Health and Care Research; Cancer Research UK","keywords":"Chimeric antigen receptor; Oncolytic virus; Cancer research; T-cell receptor; T cell; Antigen; Biology; Vesicular stomatitis virus; Glioma; Immunotherapy; Immunology; Melanoma; Virology; Immune system; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000274837,0.0005468446,0.0004555134,0.0004794626,0.0001195342,0.0004136981,0.0002224961,0.000376702,0.001210736],"category_scores_gemma":[0.0001421914,0.0001995217,0.0002648894,0.0001714334,0.0002928011,0.0003469399,0.0002227616,0.001307836,0.0003909855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404413,"about_ca_system_score_gemma":0.0002708203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004079037,"about_ca_topic_score_gemma":0.0006674044,"domain_scores_codex":[0.9997577,0.00003962594,0.00002075482,0.00005652774,0.00005207371,0.00007329242],"domain_scores_gemma":[0.9998441,0.00002907409,0.00004269423,0.00002263662,0.00001608059,0.00004542108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001605211,0.0001153943,0.0000792397,0.00002263914,0.000004873766,0.00001453095,0.00001681981,0.0001446461,0.996897,0.0001342851,0.00006440016,0.002345649],"study_design_scores_gemma":[0.00006494378,0.001365003,0.0007131472,0.000006652938,0.00002400348,0.0001203287,0.00001191195,0.001379645,0.9943439,0.00004225158,0.001924653,0.000003550393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892249,0.001328126,0.006199313,0.0001506545,0.00006038353,0.00008915388,0.0003193335,0.0003456202,0.002282585],"genre_scores_gemma":[0.9912171,0.0007646048,0.004202256,0.00006080918,0.00003124719,0.00006162794,0.0003504711,0.00006628961,0.003245648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001210736,"threshold_uncertainty_score":0.004050374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03534674777181349,"score_gpt":0.3319631336615451,"score_spread":0.2966163858897316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}