{"id":"W4224051649","doi":"10.4049/jimmunol.2101007","title":"Zebrafish CERKL Enhances Host TBK1 Stability and Simultaneously Degrades Viral Protein via Ubiquitination Modulation","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China Stem Cell and Translational Research; National Natural Science Foundation of China","keywords":"Biology; Ubiquitin; Zebrafish; Virus; Cell biology; Virology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001237841,0.000154858,0.0003054812,0.0001561483,0.0005495175,0.00001173083,0.000372561,0.0001109841,0.0008636318],"category_scores_gemma":[0.0002719562,0.0001107107,0.00008492597,0.0001094805,0.0003743856,0.000165139,0.0002087197,0.0007465293,0.00001796737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001185802,"about_ca_system_score_gemma":0.00008453114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006461153,"about_ca_topic_score_gemma":0.0000168854,"domain_scores_codex":[0.9970672,0.00193137,0.0005383156,0.0001265421,0.00007130062,0.0002652897],"domain_scores_gemma":[0.9986039,0.0004649193,0.0005380714,0.0002062933,0.0001757202,0.00001107508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003167785,0.0001279105,0.0001116982,0.000007301532,0.0001862382,0.000004656111,0.001773752,0.00002399979,0.9895459,0.0002833768,0.00005803624,0.004709327],"study_design_scores_gemma":[0.001654389,0.003751086,0.01229682,0.00002426953,0.00006970837,0.002715817,0.003923775,0.00007345787,0.9693358,0.001092162,0.004873696,0.0001890273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909465,0.006143248,0.0005334695,0.001403507,0.0005910485,0.0002662626,0.00001090771,0.00002005241,0.00008504909],"genre_scores_gemma":[0.9991265,0.0001344273,0.00003524842,0.0001120949,0.0000274714,0.00001239605,0.000009158198,0.00001312561,0.0005295963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02021012,"threshold_uncertainty_score":0.9456163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036973015549136,"score_gpt":0.2298476667766882,"score_spread":0.2194779366211969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}