{"id":"W4224051649","doi":"10.4049/jimmunol.2101007","title":"Zebrafish CERKL Enhances Host TBK1 Stability and Simultaneously Degrades Viral Protein via Ubiquitination Modulation","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China Stem Cell and Translational Research; National Natural Science Foundation of China","keywords":"Biology; Ubiquitin; Zebrafish; Virus; Cell biology; Virology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001041315,0.0003334717,0.0002481314,0.0001939001,0.0001681542,0.0002044823,0.0001560655,0.0002521978,0.001442604],"category_scores_gemma":[0.00008847866,0.0001086445,0.0002677178,0.00007154287,0.0002511636,0.0002543984,0.0002261306,0.0004687861,0.0002905789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005331534,"about_ca_system_score_gemma":0.0002512459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007030492,"about_ca_topic_score_gemma":0.001237685,"domain_scores_codex":[0.9999014,0.000009186392,0.000009363486,0.00002743476,0.00002091354,0.00003165693],"domain_scores_gemma":[0.9999239,0.000004447631,0.00002713013,0.00000782817,0.00001193822,0.0000246658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021358,0.000008521263,0.0001305196,0.00004079151,0.000002992226,0.00002374239,0.000006214849,0.00002712588,0.9991041,0.00004312442,0.00002229262,0.0004883667],"study_design_scores_gemma":[0.0000187772,0.0001673758,0.002420189,0.000005168436,0.00001446491,0.000104775,0.00001868617,0.0005348584,0.9954565,0.0000350363,0.001219623,0.000004602105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944587,0.001565106,0.002022713,0.0001322021,0.00003660097,0.00001946969,0.0002633288,0.0001210301,0.001380701],"genre_scores_gemma":[0.9953536,0.0003622941,0.001155096,0.0000497815,0.000006444273,0.00001933287,0.0002125396,0.00001566639,0.002825346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442604,"threshold_uncertainty_score":0.004826009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036973015549136,"score_gpt":0.2298476667766882,"score_spread":0.2194779366211969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}