{"id":"W4224081775","doi":"10.3390/curroncol29040229","title":"Blockade of ALDH in Cisplatin-Resistant Ovarian Cancer Stem Cells In Vitro Synergistically Enhances Chemotherapy-Induced Cell Death","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Cisplatin; Ovarian cancer; Medicine; Pharmacology; Cancer stem cell; Cancer research; Apoptosis; Chemotherapy; Cytotoxic T cell; Taxane; Cancer; Cytotoxicity; Cancer cell; Internal medicine; In vitro; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000234668,0.0003444118,0.0004481887,0.0003328733,0.0001239092,0.0002300509,0.0001887058,0.0002025402,0.0008025568],"category_scores_gemma":[0.0001328129,0.000161362,0.0002790169,0.0002564899,0.0001764474,0.000207074,0.0001773319,0.0006408991,0.0001844563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002028651,"about_ca_system_score_gemma":0.0002906986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004575167,"about_ca_topic_score_gemma":0.001085505,"domain_scores_codex":[0.999754,0.00006607761,0.00003268955,0.00003244741,0.00007631242,0.00003858903],"domain_scores_gemma":[0.9999048,0.00002804605,0.00001516444,0.00001483173,0.00001251283,0.00002467313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003416932,0.0002699336,0.000271638,0.00008978701,0.00002269137,0.00005985538,0.00004843004,0.0002156865,0.9955451,0.0001116427,0.0001223008,0.002901261],"study_design_scores_gemma":[0.00006798642,0.002173932,0.002238024,0.000006681566,0.00002972198,0.0001354836,0.00002501262,0.00115092,0.9923187,0.00003870072,0.001810172,0.000004634642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944747,0.002482577,0.001265352,0.0001109744,0.00006813427,0.00007798606,0.0002323744,0.00004952172,0.001238292],"genre_scores_gemma":[0.9946923,0.001733328,0.00182213,0.00005945834,0.00002462463,0.00008868541,0.0004524118,0.000007807595,0.001119235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008025568,"threshold_uncertainty_score":0.002684772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03934616603728672,"score_gpt":0.3261334536577452,"score_spread":0.2867872876204585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}