{"id":"W4224110651","doi":"10.3390/genes13040691","title":"Elevated Expression of miR-200c/141 in MDA-MB-231 Cells Suppresses MXRA8 Levels and Impairs Breast Cancer Growth and Metastasis In Vivo","year":2022,"lang":"en","type":"article","venue":"Genes","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; University of Guelph","keywords":"Metastasis; Breast cancer; Cancer research; Transfection; In vivo; Cancer; Downregulation and upregulation; Cancer cell; Cell culture; Biology; Mesenchymal stem cell; Pathology; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001634511,0.0002370781,0.0003401275,0.0001913403,0.0001679297,0.0003559077,0.0001537017,0.0002560682,0.001033009],"category_scores_gemma":[0.0001311605,0.000167387,0.0002451427,0.0001337379,0.0001734776,0.0001157616,0.00013318,0.0005255262,0.0004479356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667102,"about_ca_system_score_gemma":0.0002935194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007784879,"about_ca_topic_score_gemma":0.001093314,"domain_scores_codex":[0.999793,0.00002849067,0.00002504237,0.00002795107,0.00008281628,0.0000427226],"domain_scores_gemma":[0.9998914,0.00001911803,0.0000334105,0.00001644651,0.00001452464,0.00002515672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000426882,0.00001939857,0.0001366931,0.00001590049,0.00000287351,0.00001882024,0.00001016513,0.00002321787,0.9991699,0.00004295405,0.00002733235,0.0004901767],"study_design_scores_gemma":[0.00001041055,0.0004196731,0.004153502,0.000003238116,0.00001578105,0.0002064234,0.0000313137,0.0008932169,0.9912677,0.0000252295,0.002969409,0.000003964953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960926,0.001073527,0.001219155,0.00007789416,0.00002553012,0.00003004568,0.0003980291,0.0001176954,0.0009655167],"genre_scores_gemma":[0.9945098,0.0005581586,0.001554082,0.00004400174,0.000007068912,0.00004866788,0.0008817654,0.00002135651,0.002375077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033009,"threshold_uncertainty_score":0.003455758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009093814952789804,"score_gpt":0.2398281540235765,"score_spread":0.2307343390707867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}