{"id":"W4224211440","doi":"10.3390/molecules27092655","title":"Elucidating Sequence and Structural Determinants of Carbohydrate Esterases for Complete Deacetylation of Substituted Xylans","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Biofuel production and bioconversion","field":"Engineering","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Argonne National Laboratory; European Research Council; Kungl. Skogs- och Lantbruksakademien","keywords":"Acetylation; Chemistry; Carbohydrate-binding module; Enzyme; Hemicellulose; Stereochemistry; Xylan; Structural motif; Hydrolase; Esterase; Biochemistry; Serine; Peptide sequence; Crystal structure; Glycoside hydrolase; Cellulose; Crystallography; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304594,0.0001925001,0.0002158272,0.0001252539,0.00007263132,0.000285665,0.000243489,0.0002080342,0.0004521251],"category_scores_gemma":[0.0002792506,0.0001116844,0.0002433458,0.000241883,0.0001306597,0.0001995702,0.0001398521,0.0002994036,0.0002397433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002198173,"about_ca_system_score_gemma":0.0001764108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009216426,"about_ca_topic_score_gemma":0.001240069,"domain_scores_codex":[0.9999154,0.00001221609,0.00001105885,0.00001862588,0.00002626257,0.00001649694],"domain_scores_gemma":[0.999863,0.00002772306,0.00004027424,0.00001565557,0.00002467825,0.00002862298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001612409,0.00005940865,0.003792378,0.00006857237,0.000009987126,0.0002604955,0.00008231572,0.0003670903,0.9911539,0.0002318667,0.00005428723,0.003758429],"study_design_scores_gemma":[0.00003991065,0.0004037012,0.07020263,0.00002199813,0.00005580879,0.001286104,0.0003157539,0.005425835,0.9154375,0.0001638928,0.006626008,0.00002086178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975055,0.0005008657,0.001426715,0.00002744273,0.000006222196,0.00001161484,0.0001431464,0.00001518167,0.0003633884],"genre_scores_gemma":[0.9956517,0.0003026616,0.002577489,0.0000162665,0.000005261353,0.000007828156,0.000757043,0.00000859363,0.0006733543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009216426,"threshold_uncertainty_score":0.001832604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02653155048150672,"score_gpt":0.2441062358898181,"score_spread":0.2175746854083114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}