{"id":"W4224215371","doi":"10.3390/ijms23084443","title":"A Non-Hazardous Deparaffinization Protocol Enables Quantitative Proteomics of Core Needle Biopsy-Sized Formalin-Fixed and Paraffin-Embedded (FFPE) Tissue Specimens","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Warren Y. Soper Charitable Trust; Jewish General Hospital; Terry Fox Research Institute; Fonds de Recherche du Québec - Santé; Fondation De Famille Alvin Segal; Canadian Institutes of Health Research; Genome Canada; McGill University","keywords":"Proteome; In situ; Chemistry; Xylene; Proteomics; Chromatography; Pathology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008165089,0.00128937,0.0005995882,0.0008049392,0.0005574336,0.0006030328,0.0005609187,0.0006336621,0.004484313],"category_scores_gemma":[0.0007540272,0.0005307675,0.0005005947,0.0006949254,0.0005416416,0.0005406046,0.0006177966,0.001214556,0.005500557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002361295,"about_ca_system_score_gemma":0.0006526016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002778955,"about_ca_topic_score_gemma":0.0008395835,"domain_scores_codex":[0.9991794,0.0001205107,0.00008658481,0.0003212886,0.0002254014,0.0000668063],"domain_scores_gemma":[0.9993024,0.0001690634,0.0001413843,0.0001780679,0.0001521168,0.00005699693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002517369,0.00002385625,0.0001876928,0.0001660043,0.000008301591,0.00007220583,0.00002554893,0.00005346904,0.991954,0.0001847831,0.0005477899,0.006751087],"study_design_scores_gemma":[0.00001450969,0.0002615958,0.006463605,0.00005618993,0.00005878381,0.00150231,0.0000396933,0.001070532,0.9440652,0.0004629547,0.0459686,0.0000360407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.103427,0.00482223,0.8743156,0.0004871367,0.0004279207,0.001396941,0.003481467,0.004403787,0.007237817],"genre_scores_gemma":[0.1483205,0.009473817,0.8124752,0.0007623847,0.0002223645,0.002977492,0.01247264,0.001365834,0.01192979],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004484313,"threshold_uncertainty_score":0.01500154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02205553408556847,"score_gpt":0.3435499793196195,"score_spread":0.321494445234051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}