{"id":"W4224216547","doi":"10.3390/curroncol29050242","title":"Enrichment-Free Single-Cell Detection and Morphogenomic Profiling of Myeloma Patient Samples to Delineate Circulating Rare Plasma Cell Clones","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; National Center for Advancing Translational Sciences; Leukemia and Lymphoma Society","keywords":"Bone marrow; Multiple myeloma; Plasma cell; Plasma cell leukemia; Pathology; Monoclonal gammopathy of undetermined significance; Malignancy; Plasma cell neoplasm; Medicine; Circulating tumor cell; Cancer research; Biology; Monoclonal; Cancer; Antibody; Immunology; Monoclonal antibody; Metastasis; Internal medicine; Plasmacytoma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001668868,0.0002011522,0.0002518213,0.0005603154,0.0002066162,0.0002745861,0.0001381871,0.0003187322,0.0005791956],"category_scores_gemma":[0.0003141048,0.0001019157,0.000155824,0.0003439114,0.0001713526,0.0000882594,0.0002270503,0.0002445572,0.000200639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008638803,"about_ca_system_score_gemma":0.00009795264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004432392,"about_ca_topic_score_gemma":0.0007244235,"domain_scores_codex":[0.9997898,0.0000222073,0.00001358539,0.000074221,0.0000743705,0.00002590878],"domain_scores_gemma":[0.9999038,0.00002786713,0.00001920699,0.00001253282,0.00002199607,0.00001459393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001600271,0.00003114816,0.03148954,0.00004169651,0.00002022848,0.0002294319,0.0001865684,0.0002259488,0.9591823,0.00004256044,0.0000657401,0.008324765],"study_design_scores_gemma":[0.00002374488,0.0006697227,0.4338207,0.00001600682,0.0001217272,0.004935972,0.0003679971,0.00717529,0.5487436,0.0002185185,0.003886779,0.00001985212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901031,0.0004597419,0.008444045,0.00003115569,0.000007400561,0.00004943841,0.0004617129,0.00006440523,0.0003788524],"genre_scores_gemma":[0.9867753,0.0002629022,0.01113296,0.00006670578,0.00000927661,0.0000705873,0.001104646,0.00002395829,0.000553674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005791956,"threshold_uncertainty_score":0.001937628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09271894927963167,"score_gpt":0.3368746487033278,"score_spread":0.2441556994236961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}