{"id":"W4224219689","doi":"10.1080/21505594.2022.2065962","title":"The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε","year":2022,"lang":"en","type":"article","venue":"Virulence","topic":"Animal Disease Management and Epidemiology","field":"Agricultural and Biological Sciences","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Key Research and Development Program of China; Priority Academic Program Development of Jiangsu Higher Education Institutions; Jiangsu Agricultural Science and Technology Independent Innovation Fund; Natural Science Foundation of Beijing Municipality; National Natural Science Foundation of China","keywords":"African swine fever virus; Biology; Innate immune system; IRF3; DNA virus; RIG-I; Virology; TANK-binding kinase 1; IκB kinase; Stimulator of interferon genes; Virus; Interferon; Sting; RNA interference; Immune system; Cell biology; Signal transduction; Kinase; Gene; Genetics; NF-κB; Protein kinase A; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001437031,0.0003816256,0.0002651906,0.0001591855,0.0001162817,0.0001998722,0.000193512,0.0002099121,0.001108545],"category_scores_gemma":[0.0001023606,0.00008030428,0.0003915954,0.0001134619,0.0002189666,0.0001610742,0.000118664,0.0004034729,0.0003062836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002312133,"about_ca_system_score_gemma":0.000301551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005454851,"about_ca_topic_score_gemma":0.0005887165,"domain_scores_codex":[0.9998921,0.00001926657,0.00001212516,0.00001451268,0.00003253078,0.0000293634],"domain_scores_gemma":[0.9999503,0.000008036614,0.00001593696,0.000005366451,0.000007023115,0.00001334107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001898565,0.00004527647,0.0002162437,0.00003837539,0.00001167489,0.00007303159,0.000006311481,0.00009762394,0.9978343,0.00006917888,0.00008700508,0.001331206],"study_design_scores_gemma":[0.00005146676,0.0004510377,0.001882001,0.000003082783,0.00002356212,0.0002891663,0.00001853475,0.001259137,0.9935638,0.00003169378,0.002421723,0.000004582154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941145,0.001981638,0.002361152,0.0001442806,0.00003739922,0.00003187498,0.0003125533,0.00006628294,0.0009504699],"genre_scores_gemma":[0.9948525,0.001161269,0.001649174,0.00005921845,0.00001122091,0.00002199006,0.0007139408,0.00001803606,0.001512552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108545,"threshold_uncertainty_score":0.003708482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747614322802616,"score_gpt":0.2059654113800239,"score_spread":0.1884892681519978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}