{"id":"W4224221911","doi":"10.1158/1055-9965.epi-21-1003","title":"Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region","year":2022,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; U.S. Department of Health and Human Services; Cancer Research UK; National Institutes of Health; Brigham and Women's Hospital; World Health Organization","keywords":"Colorectal cancer; Genome-wide association study; Allele; Single-nucleotide polymorphism; SNP; Genotype; Genetics; Oncology; Medicine; Internal medicine; Biology; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008167177,0.0009470938,0.001221445,0.001138618,0.0004946478,0.001301437,0.001247596,0.0009422079,0.004220277],"category_scores_gemma":[0.01734383,0.0004128471,0.002142606,0.001993484,0.0008183472,0.0005157907,0.001034035,0.00108688,0.0002524735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002984719,"about_ca_system_score_gemma":0.0009090971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005624494,"about_ca_topic_score_gemma":0.009788944,"domain_scores_codex":[0.9947568,0.002735171,0.000315536,0.001466162,0.0005064743,0.0002198735],"domain_scores_gemma":[0.9813961,0.0134439,0.001941404,0.001890393,0.0006631385,0.0006651102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002980027,0.0001036783,0.9376603,0.0005186591,0.00835758,0.001043916,0.000259081,0.002434615,0.01161552,0.0007244101,0.0008388451,0.03346333],"study_design_scores_gemma":[0.0002677399,0.0005403145,0.9759614,0.0001037084,0.004464149,0.0009427626,0.00012721,0.01106094,0.001532396,0.002990403,0.00196919,0.00003974478],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607397,0.006032483,0.02884192,0.001249303,0.000119498,0.00007989474,0.00115584,0.0003416482,0.001439782],"genre_scores_gemma":[0.9933051,0.0003577666,0.005439948,0.0001780145,0.00006358862,0.00003011348,0.0003404713,0.00004092907,0.0002440229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008167177,"threshold_uncertainty_score":0.04319268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2252822303443738,"score_gpt":0.4754605484784372,"score_spread":0.2501783181340633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}