{"id":"W4224224159","doi":"10.21203/rs.3.rs-1523495/v1","title":"Circulating Tumor Cells Detected in Follow-up Predict Survival Outcomes in Tri- modality Management of Advanced Non-Metastatic Esophageal Cancer: A Secondary Analysis of the QUINTETT Randomized Trial","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Western University","funders":"Lawson Health Research Institute","keywords":"Medicine; Esophageal cancer; Hazard ratio; Interquartile range; Internal medicine; Oncology; Radiation therapy; Chemoradiotherapy; Neoadjuvant therapy; Epirubicin; Randomized controlled trial; Fluorouracil; Esophagectomy; Chemotherapy; Confidence interval; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003546958,0.0006394528,0.001373776,0.0002237206,0.0002139049,0.0007331291,0.0005420925,0.0007579142,0.004281344],"category_scores_gemma":[0.005109592,0.0001801839,0.003447093,0.0003289378,0.0004127008,0.000657952,0.0004471867,0.001374814,0.0002513372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004053283,"about_ca_system_score_gemma":0.0004835559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004982618,"about_ca_topic_score_gemma":0.0009611433,"domain_scores_codex":[0.9983278,0.001068265,0.00009883514,0.0002883109,0.0001211122,0.00009571312],"domain_scores_gemma":[0.9954791,0.001883233,0.001494913,0.0003628709,0.0003044864,0.0004753798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8986197,0.001577873,0.06180135,0.001933731,0.01175865,0.0001444473,0.00005679913,0.0009852463,0.001797136,0.0002628593,0.00245872,0.01860353],"study_design_scores_gemma":[0.5485047,0.1360374,0.2617806,0.0005874299,0.0330011,0.0008349722,0.000150876,0.009482282,0.002752328,0.001893899,0.004857468,0.0001169185],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990542,0.004729224,0.0007198055,0.0004374399,0.0002313672,0.0004392077,0.001746081,0.0000239771,0.001130898],"genre_scores_gemma":[0.9957888,0.0005131704,0.0004550669,0.0002750656,0.0002195189,0.0004487474,0.001579025,0.000007144123,0.0007135728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004281344,"threshold_uncertainty_score":0.0187583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04795231477764855,"score_gpt":0.3982654303508619,"score_spread":0.3503131155732134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}