{"id":"W4224224424","doi":"10.1016/j.chom.2022.03.033","title":"A secondary metabolite drives intraspecies antagonism in a gut symbiont that is inhibited by cell-wall acetylation","year":2022,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Office of the Vice Chancellor for Research and Graduate Education, University of Wisconsin-Madison; National Institute of Food and Agriculture; National Institutes of Health; College of Agricultural and Life Sciences; Wisconsin Alumni Research Foundation; University of Wisconsin-Madison; U.S. Department of Agriculture","keywords":"Biology; Polyketide synthase; Mutant; Gene; Acetylation; Metabolite; Secondary metabolite; Microbiology; Polyketide; Genetics; Biochemistry; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002679996,0.0002652833,0.0002658786,0.0001268014,0.0002480134,0.00004918675,0.00027165,0.0001661063,0.0004180416],"category_scores_gemma":[0.000004801886,0.000292384,0.0001269424,0.0001974594,0.00007028581,0.00001095785,0.0003490187,0.0003712381,0.00003016231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008520948,"about_ca_system_score_gemma":0.0001938238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001894346,"about_ca_topic_score_gemma":0.00005379214,"domain_scores_codex":[0.9982985,0.0001821732,0.0003383785,0.0005853552,0.0001191158,0.0004764505],"domain_scores_gemma":[0.9993026,0.00001345838,0.0001674934,0.0003747739,0.00004100725,0.0001006207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007334491,0.0002123978,0.001202584,0.00006222256,0.00001664598,0.00000561149,0.001287298,0.000004808874,0.9657922,0.000007231378,0.03112138,0.0002142209],"study_design_scores_gemma":[0.0009122479,0.0001243075,0.003542191,0.00000530711,0.00001609499,0.00001432619,0.000617812,0.000006446769,0.6931497,0.0000084032,0.3013633,0.0002398795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832572,0.0134512,0.0000492347,0.0007798231,0.0002301661,0.0004027137,0.0005483206,0.00002063373,0.001260664],"genre_scores_gemma":[0.9888445,0.001637202,0.0002114524,0.003223358,0.00007411516,0.0000373334,0.001930786,0.00004486625,0.003996378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2726426,"threshold_uncertainty_score":0.9999529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005722771404059887,"score_gpt":0.2143555265205587,"score_spread":0.2086327551164988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}