{"id":"W4224224424","doi":"10.1016/j.chom.2022.03.033","title":"A secondary metabolite drives intraspecies antagonism in a gut symbiont that is inhibited by cell-wall acetylation","year":2022,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Office of the Vice Chancellor for Research and Graduate Education, University of Wisconsin-Madison; National Institute of Food and Agriculture; National Institutes of Health; College of Agricultural and Life Sciences; Wisconsin Alumni Research Foundation; University of Wisconsin-Madison; U.S. Department of Agriculture","keywords":"Biology; Polyketide synthase; Mutant; Gene; Acetylation; Metabolite; Secondary metabolite; Microbiology; Polyketide; Genetics; Biochemistry; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001402407,0.0004310965,0.0002909165,0.0002609118,0.0001693883,0.0003526559,0.0002519267,0.0002684486,0.0004475121],"category_scores_gemma":[0.0001680495,0.0001846822,0.000228097,0.0001410217,0.0002982489,0.0001720251,0.000501243,0.0003779311,0.0002111017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003117791,"about_ca_system_score_gemma":0.0001544592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000478547,"about_ca_topic_score_gemma":0.0009060713,"domain_scores_codex":[0.9997841,0.00003531286,0.0000173248,0.00005138462,0.00006586286,0.00004611089],"domain_scores_gemma":[0.9998164,0.00002992811,0.00007420691,0.00002681511,0.00001512971,0.00003751449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000313181,0.000005440573,0.0002706527,0.00000461794,0.000001477306,0.00001838794,0.000004405066,0.00001132036,0.9994211,0.00001720193,0.000003088793,0.0002109919],"study_design_scores_gemma":[0.00001529828,0.0002235333,0.02138927,0.000003787832,0.00001445188,0.0004964579,0.00006788834,0.001298494,0.9757777,0.00007733337,0.0006265462,0.000009176565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998762,0.0001824146,0.0006393008,0.00002402883,0.000003612736,0.000005787359,0.00004757114,0.00002101211,0.0003143746],"genre_scores_gemma":[0.9979383,0.0001372562,0.001044476,0.00001698472,0.000003084761,0.000009781095,0.0001336771,0.00001155797,0.0007048312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000478547,"threshold_uncertainty_score":0.002262115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005722771404059887,"score_gpt":0.2143555265205587,"score_spread":0.2086327551164988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}