{"id":"W4224226215","doi":"10.1161/circulationaha.121.058910","title":"Initial Decline (Dip) in Estimated Glomerular Filtration Rate After Initiation of Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: Insights From DAPA-HF","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; Relypsa; Defense Acquisition Program Administration; Respicardia; American Regent; Vifor Pharma; Daiichi-Sankyo; University of Glasgow; Zora Biosciences; GlaxoSmithKline; IFM Therapeutics; Janssen Research and Development; Sarepta Therapeutics; Medicines Company; Intarcia Therapeutics; Ionis Pharmaceuticals; National Institutes of Health; Regeneron Pharmaceuticals; AstraZeneca; Amarin Corporation; Sanofi Pasteur; Celladon Corporation; Esperion Therapeutics; Alnylam Pharmaceuticals; Novo Nordisk; MyoKardia; Harvard Catalyst; Eisai; Cytokinetics; FibroGen; Daiichi Sankyo Europe; Servier; Bayer; Gilead Sciences; Brigham and Women's Hospital; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Amgen; Moderna; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Ejection fraction; Dapagliflozin; Heart failure; Renal function; Cardiology; Internal medicine; Filtration fraction; Fraction (chemistry); Urology; Endocrinology; Chromatography; Diabetes mellitus; Renal blood flow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003257049,0.0004233059,0.00126879,0.000324132,0.0001045057,0.0005274053,0.0003092581,0.0003001684,0.0009777015],"category_scores_gemma":[0.003500041,0.0001669516,0.001600259,0.0002684102,0.0002666754,0.0002539307,0.0003269992,0.0007629902,0.00007369176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003278446,"about_ca_system_score_gemma":0.0006676074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005929989,"about_ca_topic_score_gemma":0.001117314,"domain_scores_codex":[0.9991653,0.0005170558,0.00005099412,0.0001069224,0.0001005094,0.00005924579],"domain_scores_gemma":[0.9966589,0.002059191,0.0007153919,0.0001609132,0.0001457984,0.0002597839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1563153,0.003083856,0.6591046,0.001858877,0.0105891,0.0002905547,0.0002254641,0.004262048,0.005173516,0.0003958706,0.001605456,0.1570954],"study_design_scores_gemma":[0.01714018,0.03536234,0.9240879,0.0001938859,0.008677344,0.0003871294,0.000107641,0.008795874,0.001726418,0.0009306247,0.002539371,0.00005118046],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912992,0.005724727,0.001101791,0.000482554,0.0000439154,0.0001136049,0.0004803789,0.00001418275,0.0007395086],"genre_scores_gemma":[0.9971962,0.0009861146,0.00097042,0.000200526,0.00009930648,0.0000710392,0.0003360838,0.000002818656,0.0001373837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003257049,"threshold_uncertainty_score":0.01722515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316029311373815,"score_gpt":0.246951857979413,"score_spread":0.2337915648656748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}