{"id":"W4224226215","doi":"10.1161/circulationaha.121.058910","title":"Initial Decline (Dip) in Estimated Glomerular Filtration Rate After Initiation of Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: Insights From DAPA-HF","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; Relypsa; Defense Acquisition Program Administration; Respicardia; American Regent; Vifor Pharma; Daiichi-Sankyo; University of Glasgow; Zora Biosciences; GlaxoSmithKline; IFM Therapeutics; Janssen Research and Development; Sarepta Therapeutics; Medicines Company; Intarcia Therapeutics; Ionis Pharmaceuticals; National Institutes of Health; Regeneron Pharmaceuticals; AstraZeneca; Amarin Corporation; Sanofi Pasteur; Celladon Corporation; Esperion Therapeutics; Alnylam Pharmaceuticals; Novo Nordisk; MyoKardia; Harvard Catalyst; Eisai; Cytokinetics; FibroGen; Daiichi Sankyo Europe; Servier; Bayer; Gilead Sciences; Brigham and Women's Hospital; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Amgen; Moderna; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Ejection fraction; Dapagliflozin; Heart failure; Renal function; Cardiology; Internal medicine; Filtration fraction; Fraction (chemistry); Urology; Endocrinology; Chromatography; Diabetes mellitus; Renal blood flow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081101,0.0001129115,0.0002036396,0.0003413895,0.00005038809,0.00001602938,0.0000189398,0.00005174914,0.00009466716],"category_scores_gemma":[0.00003088814,0.0001135771,0.00002061039,0.0004424469,0.00001908932,0.0003647301,0.00002623464,0.0001151471,0.000002119414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196147,"about_ca_system_score_gemma":0.00003114065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001283525,"about_ca_topic_score_gemma":0.000125438,"domain_scores_codex":[0.9989892,0.0001141761,0.0003034343,0.0002447276,0.0002507553,0.00009771122],"domain_scores_gemma":[0.9996011,0.0000343398,0.0001322001,0.0001304107,0.00007093509,0.00003097327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008061075,0.0004068864,0.9912664,0.00003366095,0.00003493303,0.00000634369,0.0002347192,0.002110798,0.004138398,0.00002571167,0.00001797541,0.000918051],"study_design_scores_gemma":[0.004523847,0.0002829517,0.9871035,0.00009206561,0.0000874551,5.050917e-7,0.0001358504,0.006407615,0.0009180665,0.0002534328,0.00009418126,0.0001005173],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985787,0.00006533881,0.0001972017,0.0001917741,0.00008823493,0.0007489503,0.00001244417,0.0000265538,0.00009076055],"genre_scores_gemma":[0.9973696,0.000003293049,0.0004016911,0.0001241857,0.00003470157,0.0001234594,0.001925854,0.00001440429,0.000002757857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004296817,"threshold_uncertainty_score":0.463154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316029311373815,"score_gpt":0.246951857979413,"score_spread":0.2337915648656748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}