{"id":"W4224227591","doi":"10.21203/rs.3.rs-1543785/v1","title":"Production of a canine model of Parkinson’s disease using somatic cell nuclear transfer","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Welichem Biotech (Canada)","funders":"Directorate for Biological Sciences; Korea Advanced Institute of Science and Technology; Korea Health Industry Development Institute; Chungnam National University","keywords":"Somatic cell nuclear transfer; Biology; Somatic cell; Parkinson's disease; Transgene; Phenotype; Gene; Disease; Pathology; Genetics; Medicine; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008355507,0.0005097443,0.0005402574,0.0009023826,0.0004164863,0.0005403793,0.000564602,0.0008979778,0.001991097],"category_scores_gemma":[0.0003779754,0.0003090049,0.0005612955,0.0002723799,0.0005629033,0.0003944094,0.0004254253,0.0009534037,0.0008129117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004302865,"about_ca_system_score_gemma":0.0003023334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005291634,"about_ca_topic_score_gemma":0.0007828082,"domain_scores_codex":[0.999499,0.00008230188,0.0000755395,0.00012963,0.0001522583,0.00006133124],"domain_scores_gemma":[0.9995703,0.0001032699,0.0001182644,0.00007877564,0.00004810263,0.00008129734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001555751,0.000187839,0.0004862986,0.0001751593,0.00003062631,0.0006398525,0.0001080024,0.0003091729,0.9928153,0.001323259,0.0004868893,0.003282057],"study_design_scores_gemma":[0.0002794936,0.002694118,0.004820346,0.00009141343,0.000188696,0.006514011,0.0001533023,0.006408888,0.9341666,0.0005002247,0.04413263,0.00005047501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9159425,0.003824054,0.06707734,0.0007066479,0.0006183521,0.001222785,0.002789683,0.0009877763,0.006830955],"genre_scores_gemma":[0.9477822,0.002871969,0.03606798,0.0002080307,0.00008889546,0.0007625167,0.003557406,0.000203252,0.00845782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001991097,"threshold_uncertainty_score":0.006660879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07127013569460498,"score_gpt":0.3572797896615964,"score_spread":0.2860096539669914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}