{"id":"W4224228660","doi":"10.1039/d1sm01710a","title":"The morphological role of ligand inhibitors in blocking receptor- and clathrin-mediated endocytosis","year":2022,"lang":"en","type":"article","venue":"Soft Matter","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC","keywords":"Endocytosis; Endocytic cycle; Receptor-mediated endocytosis; Biophysics; Clathrin; Cell biology; Receptor; Cell membrane; Chemistry; Membrane; Internalization; Microvesicles; Nanotechnology; Biology; Materials science; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002398762,0.0004809219,0.0002689299,0.0002217162,0.0002637752,0.0005358845,0.000361365,0.0004514421,0.0007236311],"category_scores_gemma":[0.0005901938,0.0002382633,0.000236919,0.0001263714,0.0004322405,0.0006465073,0.0002328804,0.0003814901,0.000259745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005045062,"about_ca_system_score_gemma":0.000246519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004538322,"about_ca_topic_score_gemma":0.0004448873,"domain_scores_codex":[0.9997266,0.00004987183,0.00001836839,0.0000463159,0.0001033273,0.00005551287],"domain_scores_gemma":[0.9995999,0.0001310145,0.0001602236,0.00002232596,0.00004452476,0.0000419269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009006537,0.00003161173,0.0001748821,0.0000806735,0.000007955448,0.00005147151,0.00001241479,0.0009950832,0.9957918,0.0008931169,0.00003650712,0.001834453],"study_design_scores_gemma":[0.00000866238,0.0001613957,0.001066781,0.00000620097,0.00001283153,0.0001249138,0.0000160687,0.003727447,0.9936345,0.0001339277,0.001100069,0.000007275094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715866,0.005629963,0.01587874,0.0002454065,0.00004421221,0.00005186679,0.0001183819,0.000134525,0.006310226],"genre_scores_gemma":[0.9925421,0.001773399,0.004731876,0.00006847028,0.000008980574,0.00003122534,0.00005697026,0.00002564469,0.0007612965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007236311,"threshold_uncertainty_score":0.0036605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00446979713119783,"score_gpt":0.2083143166803558,"score_spread":0.203844519549158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}