{"id":"W4224228660","doi":"10.1039/d1sm01710a","title":"The morphological role of ligand inhibitors in blocking receptor- and clathrin-mediated endocytosis","year":2022,"lang":"en","type":"article","venue":"Soft Matter","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC","keywords":"Endocytosis; Endocytic cycle; Receptor-mediated endocytosis; Biophysics; Clathrin; Cell biology; Receptor; Cell membrane; Chemistry; Membrane; Internalization; Microvesicles; Nanotechnology; Biology; Materials science; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113827,0.00007800719,0.00009078674,0.00002255534,0.00009031715,0.000009569628,0.0001036147,0.00005167431,0.00009031079],"category_scores_gemma":[0.000018239,0.0000555142,0.00003611665,0.00006113494,0.00007128716,0.000001627509,0.0002023923,0.0001219956,0.000003635883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006608464,"about_ca_system_score_gemma":0.00001473197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000181719,"about_ca_topic_score_gemma":0.000008550416,"domain_scores_codex":[0.9993959,0.00004962643,0.0001473706,0.0001720926,0.00008884816,0.0001461567],"domain_scores_gemma":[0.9997527,0.00002385944,0.00004909121,0.0001373581,0.00001211066,0.00002489992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003945905,0.00001681069,0.08369473,0.000003296891,0.000006242841,0.000002019366,0.0000698402,0.000003528024,0.9140469,0.000002822979,0.0008518731,0.001262434],"study_design_scores_gemma":[0.000348762,0.0001023711,0.0147671,0.000003317486,0.000007695174,0.00002869963,0.0002549053,0.000002556408,0.9427761,0.00002867157,0.0415899,0.00008992528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988716,0.000393247,6.661438e-7,0.000297901,0.0001220361,0.00009653676,0.00001650745,0.000003910144,0.000197567],"genre_scores_gemma":[0.9993014,0.00004322131,0.00001991868,0.000341973,0.00008395427,0.00003077099,0.00002972836,0.000009246958,0.0001397321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06892763,"threshold_uncertainty_score":0.2263803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00446979713119783,"score_gpt":0.2083143166803558,"score_spread":0.203844519549158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}