{"id":"W4224231151","doi":"10.3390/biomedicines10050938","title":"Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Environmental Health Sciences; Michigan State University; International Myeloma Foundation","keywords":"Proteasome; Cancer research; Multiple myeloma; Ubiquitin; Bortezomib; Protein degradation; Transcription factor; Biology; Enhancer; Proteasome inhibitor; Chemistry; Cell biology; Gene; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120026,0.0001824718,0.0001914229,0.0001661272,0.00007103816,0.0001777748,0.0001160595,0.0001720519,0.0008009932],"category_scores_gemma":[0.00006883904,0.00008017237,0.000180823,0.000103273,0.0001380483,0.00008790209,0.00008717144,0.000335098,0.00015391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613691,"about_ca_system_score_gemma":0.0001370932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002321928,"about_ca_topic_score_gemma":0.0004593563,"domain_scores_codex":[0.9999456,0.000008740285,0.000004587688,0.000008695098,0.00001783941,0.0000144846],"domain_scores_gemma":[0.9999608,0.000008383856,0.00001324841,0.000003570926,0.000003376708,0.00001063944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001468118,0.00006984041,0.0001091743,0.00003061524,0.000005491838,0.00003310859,0.000005049042,0.000120295,0.997341,0.00009251548,0.00003698296,0.002009125],"study_design_scores_gemma":[0.00004795223,0.00149575,0.002654796,0.000002846303,0.00001707038,0.000198936,0.000006780407,0.0009495601,0.9927884,0.00003230552,0.001801647,0.000004077237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938869,0.002873404,0.001407076,0.00007642256,0.00002720604,0.00002485053,0.0001215057,0.00009308695,0.001489422],"genre_scores_gemma":[0.9969217,0.001103798,0.0007733742,0.00004218692,0.000008864837,0.00001169184,0.0002113302,0.000008509684,0.000918472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008009932,"threshold_uncertainty_score":0.002679586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0252435630480442,"score_gpt":0.2360311455767505,"score_spread":0.2107875825287063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}