{"id":"W4224231151","doi":"10.3390/biomedicines10050938","title":"Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Environmental Health Sciences; Michigan State University; International Myeloma Foundation","keywords":"Proteasome; Cancer research; Multiple myeloma; Ubiquitin; Bortezomib; Protein degradation; Transcription factor; Biology; Enhancer; Proteasome inhibitor; Chemistry; Cell biology; Gene; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000526393,0.0002198455,0.0002432903,0.000105794,0.0001783224,0.00001669958,0.0001871486,0.00009405981,0.0001128096],"category_scores_gemma":[0.0001764877,0.0002034183,0.00005145443,0.000258966,0.0002139343,0.000007323931,0.000362154,0.0001758285,0.000002648321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003751981,"about_ca_system_score_gemma":0.000108855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001711873,"about_ca_topic_score_gemma":0.000142227,"domain_scores_codex":[0.9984056,0.000214118,0.0002349806,0.0005892911,0.0002050165,0.0003510113],"domain_scores_gemma":[0.9993335,0.00001953712,0.0001104922,0.0003726985,0.00005190104,0.0001118686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003105965,0.0001786017,0.00728925,0.0001214383,0.00001546021,0.00001515652,0.0001425293,0.000001072174,0.9884517,0.00001164371,0.0001004801,0.00336208],"study_design_scores_gemma":[0.001117292,0.0006294479,0.01730336,0.00003895455,0.000006313752,0.00002126771,0.0001579836,0.0001060125,0.9750968,0.00006992669,0.005202197,0.0002505039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960918,0.001552128,0.00006866671,0.000472539,0.0001024911,0.001372498,0.00007858311,0.00002994815,0.000231372],"genre_scores_gemma":[0.9981453,0.00003348777,0.0003295215,0.00009816413,0.0001692118,0.0007347921,0.00007715949,0.00002685902,0.0003854871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01335495,"threshold_uncertainty_score":0.8295159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0252435630480442,"score_gpt":0.2360311455767505,"score_spread":0.2107875825287063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}