{"id":"W4224234032","doi":"10.1002/ijc.34015","title":"Diabetes mellitus in relation to colorectal tumor molecular subtypes: A pooled analysis of more than 9000 cases","year":2022,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Heart, Lung, and Blood Institute; School of Public Health, Imperial College London; Instituto de Salud Carlos III; National Health and Medical Research Council; Centers for Disease Control and Prevention; National Institutes of Health; Insamlingsstiftelsen Diabetes Wellness Network Sverige; Health Research Fund of Central Denmark Region; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Medical Research Council; Medical Research Council Canada; Cancer Council Victoria; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Umeå Universitet; Vetenskapsrådet; Canadian Institutes of Health Research; Cancerfonden; Institut National de la Santé et de la Recherche Médicale; Ministerul Cercetării şi Inovării; Imperial College London; Ontario Ministry of Research and Innovation; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Bundesministerium für Bildung und Forschung; Harvard T.H. Chan School of Public Health; National Institute for Health and Care Research; American Cancer Society; VicHealth; World Cancer Research Fund; Danish Cancer Society Research Center; Génome Québec; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; Fred Hutchinson Cancer Research Center; Johns Hopkins University; Kræftens Bekæmpelse; Canadian Cancer Society Research Institute; McGill University; Brigham and Women's Hospital; World Health Organization; Cancer Research UK; NIHR Imperial Biomedical Research Centre; Centre International de Recherche sur le Cancer; U.S. Department of Health and Human Services","keywords":"Colorectal cancer; Oncology; Internal medicine; Medicine; KRAS; Diabetes mellitus; Microsatellite instability; Cancer; Epidemiology; Allele; Biology; Endocrinology; Genetics; Microsatellite; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002605638,0.00009420263,0.0002491197,0.0004096423,0.00002102765,0.00001309016,0.0003028329,0.00003068535,0.0002846809],"category_scores_gemma":[0.00009636357,0.00009225317,0.000216157,0.0003639835,0.00002813175,0.000009284819,0.00008412769,0.0001099018,4.32949e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001167204,"about_ca_system_score_gemma":0.0001892961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001198575,"about_ca_topic_score_gemma":0.0002155996,"domain_scores_codex":[0.9987702,0.00008280973,0.0003977074,0.0001510005,0.0004690056,0.0001293044],"domain_scores_gemma":[0.9991608,0.00002331176,0.0003265735,0.00009761319,0.0003326739,0.00005899995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001824944,0.0003379727,0.2487199,0.00001764832,0.007541152,0.000156726,0.0008387562,0.1738784,0.5297309,0.0002084882,0.0008806383,0.03586451],"study_design_scores_gemma":[0.002616301,0.000893986,0.3163036,0.00008889932,0.001770747,0.00003274117,0.0006607552,0.001585453,0.6003453,0.0002120321,0.07502475,0.0004654986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9297936,0.06928018,0.00007052155,0.0001459452,0.000460109,0.00006680283,0.0001369699,0.000001414762,0.00004444086],"genre_scores_gemma":[0.9970217,0.002028779,0.00007514634,0.0005979636,0.0001672196,0.00003248429,0.00004268232,0.0000114434,0.0000225318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1722929,"threshold_uncertainty_score":0.3761975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006227953973449415,"score_gpt":0.2802264162948674,"score_spread":0.2739984623214179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}