{"id":"W4224234897","doi":"10.1016/j.celrep.2022.110728","title":"Human IL-10-producing B cells have diverse states that are induced from multiple B cell subsets","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Regulatory B cells; Immunophenotyping; Biology; B cell; Interleukin 10; Immunology; Cytokine; Immune system; Tumor necrosis factor alpha; Flow cytometry; Cell biology; T cell; Naive B cell; Antigen-presenting cell; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001639641,0.0001933726,0.00011672,0.0002775172,0.0001325641,0.0005149919,0.00009706985,0.0001372469,0.003154948],"category_scores_gemma":[0.0002637287,0.0001197856,0.0001096532,0.0001721101,0.0002425238,0.0002036241,0.0001905386,0.0004329112,0.0005685976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001623333,"about_ca_system_score_gemma":0.0001831049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002717481,"about_ca_topic_score_gemma":0.0004980317,"domain_scores_codex":[0.9998569,0.00003502197,0.00001430295,0.00003132288,0.00002927984,0.00003308545],"domain_scores_gemma":[0.9998316,0.00004636329,0.00004169038,0.00002180763,0.00001522005,0.00004326564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002407801,0.00004541563,0.005090744,0.00003770078,0.0000129738,0.00008682661,0.00006670693,0.00003789229,0.9892441,0.000178387,0.0000648522,0.004893625],"study_design_scores_gemma":[0.00005892514,0.001243926,0.09665857,0.00003498525,0.00009245214,0.00279275,0.000211278,0.0003168561,0.889437,0.0004611742,0.008675618,0.00001640267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991993,0.001971336,0.002605972,0.00007819503,0.00002929954,0.00002405545,0.0002809511,0.0000594281,0.00295774],"genre_scores_gemma":[0.9961361,0.0007324977,0.0009486526,0.00006738046,0.00002144481,0.00003224832,0.0005969724,0.00001297012,0.001451634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003154948,"threshold_uncertainty_score":0.01055431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02462927757056634,"score_gpt":0.2227519762253972,"score_spread":0.1981226986548309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}