{"id":"W4224238498","doi":"10.1016/j.anndiagpath.2022.151953","title":"HER2 testing in metastatic breast cancer – Is reflex ISH testing necessary on HER2 IHC-equivocal (2+) cases?","year":2022,"lang":"en","type":"article","venue":"Annals of Diagnostic Pathology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"Medicine; Immunohistochemistry; Context (archaeology); Breast cancer; Pathology; Metastasis; Biopsy; Cancer; Metastatic breast cancer; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001904166,0.0003206701,0.0008617154,0.0004946431,0.0001854494,0.00001662349,0.0003797663,0.000109165,0.001754959],"category_scores_gemma":[0.0209499,0.0003245285,0.0001195613,0.001520357,0.0003116739,0.00009177627,0.0004072716,0.00102232,0.00003935937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002321221,"about_ca_system_score_gemma":0.0009675758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004451232,"about_ca_topic_score_gemma":0.0002639944,"domain_scores_codex":[0.9957525,0.0007497014,0.0008364659,0.0007628119,0.0008708253,0.001027766],"domain_scores_gemma":[0.9865922,0.01170224,0.0003160975,0.0006407163,0.0004606187,0.00028816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007238303,0.002381659,0.6485865,0.0009912753,0.0001627392,0.04350726,0.001681924,0.001729327,0.00518368,0.0001182587,0.03041541,0.2645181],"study_design_scores_gemma":[0.004755337,0.01023322,0.9492286,0.00301088,0.00026658,0.01333788,0.002687532,0.002067288,0.006496792,0.00200501,0.004881977,0.001028854],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772399,0.002082314,0.000009834972,0.0152941,0.0003228406,0.0007796303,0.0007491345,0.00007608454,0.003446157],"genre_scores_gemma":[0.9886388,0.0002948299,0.0008835691,0.009030692,0.0002204952,0.0006439475,0.000034384,0.00008070491,0.0001726357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3006422,"threshold_uncertainty_score":0.9999207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2816990791093923,"score_gpt":0.4717600769175204,"score_spread":0.1900609978081281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}