{"id":"W4224240370","doi":"10.1172/jci.insight.157035","title":"Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University; Population Health Research Institute","funders":"National Center for Research Resources; National Human Genome Research Institute; National Institute on Aging; Swiss National Centre of Competence in Research Kidney Control of Homeostasis; Helmholtz Zentrum München; Canadian Institutes of Health Research; Bayer Vital; Abbott Diagnostics; Amgen; Siemens Healthineers; National Center for Advancing Translational Sciences; Medical Research Council; Università di Bologna; European Commission; Novartis Pharma; China Scholarship Council; Vifor Pharma; Ministero della Salute; National Heart, Lung, and Blood Institute; Deutsche Diabetes Gesellschaft; Amryt Pharma; Albert-Ludwigs-Universität Freiburg; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Horizon 2020 Framework Programme; National Institute of Neurological Disorders and Stroke; University of Cambridge; Fresenius Medical Care North America; AstraZeneca; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Yale University; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; National Institutes of Health; U.S. Department of Health and Human Services; National Science Foundation","keywords":"Tamm–Horsfall protein; Biology; Kidney; Kidney disease; Gene; Genetics; Immunology; Computational biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002837708,0.0003053801,0.0003917093,0.0007514482,0.0001797433,0.0005251612,0.000211873,0.0003927665,0.0025014],"category_scores_gemma":[0.0006905473,0.0001202952,0.0004802924,0.00140409,0.0001718954,0.000151441,0.000376598,0.000427837,0.0001691443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001368169,"about_ca_system_score_gemma":0.0001268271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001441916,"about_ca_topic_score_gemma":0.00253065,"domain_scores_codex":[0.9997435,0.00003940365,0.00001660246,0.0001356448,0.00003426577,0.00003056912],"domain_scores_gemma":[0.9995012,0.0001531867,0.000195559,0.00003621624,0.00003449341,0.00007942753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008871224,0.00005829028,0.8975929,0.0002976207,0.001498041,0.0008860925,0.000151262,0.0005350708,0.06728839,0.0003887835,0.001435323,0.02898104],"study_design_scores_gemma":[0.00001413255,0.00003474304,0.9954748,0.00001489098,0.0002645369,0.0005284077,0.00004701939,0.0005831221,0.001070678,0.0001742985,0.001787925,0.000005489943],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867792,0.005879377,0.002122584,0.0002893677,0.00003302542,0.00001182612,0.003972804,0.00005440507,0.0008572537],"genre_scores_gemma":[0.9939833,0.001601052,0.001339526,0.0001537929,0.00004375564,0.0000124618,0.002245744,0.00001839094,0.0006020812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0025014,"threshold_uncertainty_score":0.008368015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.124093356255393,"score_gpt":0.2990553349296985,"score_spread":0.1749619786743055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}