{"id":"W4224240370","doi":"10.1172/jci.insight.157035","title":"Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University; Population Health Research Institute","funders":"National Center for Research Resources; National Human Genome Research Institute; National Institute on Aging; Swiss National Centre of Competence in Research Kidney Control of Homeostasis; Helmholtz Zentrum München; Canadian Institutes of Health Research; Bayer Vital; Abbott Diagnostics; Amgen; Siemens Healthineers; National Center for Advancing Translational Sciences; Medical Research Council; Università di Bologna; European Commission; Novartis Pharma; China Scholarship Council; Vifor Pharma; Ministero della Salute; National Heart, Lung, and Blood Institute; Deutsche Diabetes Gesellschaft; Amryt Pharma; Albert-Ludwigs-Universität Freiburg; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Horizon 2020 Framework Programme; National Institute of Neurological Disorders and Stroke; University of Cambridge; Fresenius Medical Care North America; AstraZeneca; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Yale University; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; National Institutes of Health; U.S. Department of Health and Human Services; National Science Foundation","keywords":"Tamm–Horsfall protein; Biology; Kidney; Kidney disease; Gene; Genetics; Immunology; Computational biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137002,0.0001609784,0.0003349122,0.0001205749,0.0005631068,0.00001857425,0.00005515202,0.00002632743,0.0001822581],"category_scores_gemma":[0.001722507,0.000130629,0.0000536653,0.0003631943,0.00003828006,0.00007645888,0.0001452146,0.0002039902,0.000006023838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003066448,"about_ca_system_score_gemma":0.00016264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004483229,"about_ca_topic_score_gemma":0.000009027126,"domain_scores_codex":[0.9987662,0.0001325443,0.0002205403,0.0002998971,0.0003392604,0.0002415613],"domain_scores_gemma":[0.9988158,0.0004800489,0.00008983356,0.0001731721,0.000102055,0.0003390293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006650908,0.0002708691,0.990848,0.0001079814,0.0004596568,0.0000796539,0.003647401,0.0002391804,0.001766001,0.0001162905,0.002341386,0.00005706419],"study_design_scores_gemma":[0.001153198,0.000285283,0.9925834,0.00007954742,0.0003118159,0.000002771426,0.001650361,0.0002124204,0.00005811723,0.00009330046,0.003387769,0.0001820256],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935864,0.003866838,0.000003184027,0.001096349,0.00005199493,0.0004594195,0.0002131974,0.0001024352,0.0006202483],"genre_scores_gemma":[0.9978922,0.00001229735,0.00002239669,0.0009601237,0.00006283377,0.00006487311,0.0004665403,0.00002780621,0.0004909016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004305894,"threshold_uncertainty_score":0.5326896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.124093356255393,"score_gpt":0.2990553349296985,"score_spread":0.1749619786743055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}