{"id":"W4224240643","doi":"10.1093/brain/awac144","title":"Clearance of variant Creutzfeldt–Jakob disease prions <i>in vivo</i> by the Hsp70 disaggregase system","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Alberta Prion Research Institute; National Institutes of Health; University of Cambridge","keywords":"Biology; Proteotoxicity; Gene knockdown; Cell biology; Protein aggregation; Neurotoxicity; Neurodegeneration; Chaperone (clinical); Transgene; Hsp70; Virology; Gene; Genetics; Heat shock protein; Disease; Chemistry; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003366326,0.000107344,0.0001117533,0.00002191275,0.000176208,0.00001524295,0.0003366013,0.00003068448,0.00009810666],"category_scores_gemma":[0.00008132713,0.0000909624,0.0001076931,0.0001382695,0.00005585754,0.000003051542,0.000251926,0.00009287688,0.00000213734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002521754,"about_ca_system_score_gemma":0.00009667903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007201102,"about_ca_topic_score_gemma":0.00001253943,"domain_scores_codex":[0.9989222,0.0002293582,0.0002041663,0.0002683452,0.0001749039,0.0002009734],"domain_scores_gemma":[0.9993058,0.00003202009,0.00009826122,0.0004484598,0.00001623231,0.00009924106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001623338,0.0006414795,0.003337456,0.0003477921,0.0001393573,0.0001426943,0.0002641376,0.002773313,0.8324091,0.007559685,0.134834,0.01592763],"study_design_scores_gemma":[0.002033002,0.0003360876,0.003286019,0.0001364393,0.00007072595,0.00005440151,0.001071537,0.001634671,0.03711414,0.0002293944,0.9534725,0.0005611018],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662831,0.0259959,0.0007849097,0.003909021,0.0002359968,0.0005864752,0.001232187,0.00002626515,0.0009460778],"genre_scores_gemma":[0.9978623,0.000145863,0.00003740454,0.0007939492,0.00006462215,0.0001489442,0.00005762572,0.00001814463,0.0008710952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8186385,"threshold_uncertainty_score":0.3709339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004729875614404377,"score_gpt":0.2159213601168494,"score_spread":0.211191484502445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}