{"id":"W4224242259","doi":"10.1038/s42003-022-03333-9","title":"Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Waterloo; University of Toronto; Hospital for Sick Children","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Okinawa Institute of Science and Technology Graduate University; University of Toronto; Government of Canada","keywords":"Diphtheria toxin; Biology; Toxin; Genetics; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005432382,0.0001938269,0.0004787531,0.0001832735,0.0006543731,0.000004320178,0.00142734,0.0002280163,0.001571419],"category_scores_gemma":[0.0001123281,0.0001868562,0.0001437555,0.0002493654,0.001096292,0.00007394276,0.00107878,0.0003833407,0.00001434204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007996448,"about_ca_system_score_gemma":0.0002098772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004013969,"about_ca_topic_score_gemma":0.0001420264,"domain_scores_codex":[0.9972751,0.001346167,0.0007218999,0.0003084904,0.00004852107,0.0002998509],"domain_scores_gemma":[0.9971703,0.0003231689,0.000504632,0.00183093,0.0001453706,0.00002565749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003267303,0.0005165383,0.006823003,0.00001153799,0.0001245386,6.987575e-7,0.0002970354,0.00001376742,0.9454518,0.0434867,0.0004835046,0.002464172],"study_design_scores_gemma":[0.006805645,0.005948268,0.3003605,0.00005951453,0.0002888163,0.0007530979,0.00528299,0.0003416012,0.5203482,0.07717261,0.08140418,0.001234588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914398,0.005634401,0.0001943869,0.000217904,0.0008964833,0.000333078,0.0009196275,0.00004708795,0.0003172483],"genre_scores_gemma":[0.995901,0.0001015896,0.002079879,0.00009086647,0.00001289583,0.0001371041,0.001191613,0.00001929411,0.000465707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4251036,"threshold_uncertainty_score":0.9993413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0330696095176173,"score_gpt":0.2781773689350699,"score_spread":0.2451077594174527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}