{"id":"W4224242383","doi":"10.1002/ange.202204719","title":"Beyond Bioisosteres: Divergent Synthesis of Azabicyclohexanes and Cyclobutenyl Amines from Bicyclobutanes**","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nucleophile; Chemistry; Carbocation; Reactivity (psychology); Yield (engineering); Lewis acids and bases; Cycloaddition; Combinatorial chemistry; Aryl; Alkyl; Stereochemistry; Medicinal chemistry; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003506239,0.0006151652,0.0001925485,0.0002480226,0.0001527953,0.0005411351,0.0003664182,0.0002918869,0.001685501],"category_scores_gemma":[0.0002993711,0.0001779773,0.000163677,0.0001843351,0.0003130232,0.0006697273,0.0004005162,0.0007151105,0.001060375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00032926,"about_ca_system_score_gemma":0.0002516902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002074845,"about_ca_topic_score_gemma":0.0006301521,"domain_scores_codex":[0.9998316,0.00002678535,0.00001559256,0.00003709979,0.00004295884,0.00004603584],"domain_scores_gemma":[0.999853,0.00003074456,0.00003424287,0.0000209265,0.00002221765,0.00003893986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001523767,0.00006191048,0.0001737425,0.0001939458,0.00001090956,0.0002710105,0.0001072975,0.0004474075,0.9799872,0.004743628,0.0001705886,0.01368008],"study_design_scores_gemma":[0.00001609871,0.0003812801,0.0002870983,0.00001666954,0.000009116598,0.0003364626,0.00002787658,0.0004662449,0.9857767,0.0004921799,0.01217903,0.00001124698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8642879,0.01657019,0.0666928,0.0007071897,0.0004413135,0.000353752,0.0008293001,0.0004681077,0.04964944],"genre_scores_gemma":[0.9555171,0.005315454,0.03083888,0.0001763404,0.00005637104,0.0001391219,0.0004594628,0.00008746076,0.007409809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001685501,"threshold_uncertainty_score":0.00563854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01180080864065487,"score_gpt":0.2134160975180346,"score_spread":0.2016152888773797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}