{"id":"W4224245578","doi":"10.1016/j.jbc.2022.101951","title":"The N-terminal domain of the Agrobacterium tumefaciens telomere resolvase, TelA, regulates its DNA cleavage and rejoining activities","year":2022,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; University of Saskatchewan","keywords":"Telomere; Tn3 transposon; Biology; DNA; Telomere-binding protein; Replicon; Agrobacterium tumefaciens; Recombinase; DNA replication; Telomerase; Mutant; Molecular biology; Plasmid; Cell biology; Genetics; Gene; DNA-binding protein; Transformation (genetics); Recombination; Transposable element","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009607575,0.0003960401,0.0001750085,0.0001503737,0.0001202355,0.0002121352,0.0002346489,0.0002309328,0.0008627565],"category_scores_gemma":[0.0001027257,0.0001469048,0.0001899431,0.0001300879,0.0002884579,0.0001343672,0.0001943539,0.0004578592,0.0007308853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003241978,"about_ca_system_score_gemma":0.0002361234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005002672,"about_ca_topic_score_gemma":0.0007939159,"domain_scores_codex":[0.9998971,0.00001739251,0.000008366869,0.00002591141,0.00003258954,0.00001870306],"domain_scores_gemma":[0.9999044,0.00001994103,0.0000264091,0.00001766222,0.000009232353,0.00002231322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001891907,0.000008207475,0.00009059839,0.00001242648,9.06415e-7,0.00001791953,0.000003727934,0.00002605797,0.9991338,0.00006585581,0.00001565073,0.0006059667],"study_design_scores_gemma":[0.000008105132,0.00002837734,0.004290044,0.000004394236,0.0000054366,0.0002116143,0.00001588107,0.0006222773,0.9911982,0.00006998268,0.003541971,0.000003571879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815471,0.001648481,0.01274436,0.000144582,0.00004128778,0.00003044811,0.0008732778,0.0002781939,0.002692128],"genre_scores_gemma":[0.9911005,0.0005135152,0.004778848,0.00004115492,0.000005116342,0.00002612346,0.0009381496,0.0000375297,0.002559213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008627565,"threshold_uncertainty_score":0.002886176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008626590814221636,"score_gpt":0.2454395820039258,"score_spread":0.2368129911897042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}