{"id":"W4224249539","doi":"10.1038/s41591-022-01775-6","title":"Reimagining patient-centric cancer clinical trials: a multi-stakeholder international coalition","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Foundation Medicine; Pharmacyclics; Johns Hopkins Bloomberg School of Public Health; Weill Cornell Medical College; Genentech; Shanghai Jiao Tong University; Astellas Pharma; Eisai; Bayer HealthCare; Government of Ontario; Ontario Institute for Cancer Research; HSBC Bank USA; Baxalta; Varian Medical Systems; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; Daiichi Sankyo Europe; National Cancer Institute; Bayer; Gilead Sciences; University of Toronto; Yale University; Exelixis; Guangdong Provincial People's Hospital; Leidos; Breast Cancer Research Foundation; Sanofi; AstraZeneca; Eli Lilly and Company; Queen's University; Bloomberg L.P.; Celgene; Yale Cancer Center; Innovent Biologics; Incyte; Pfizer; National Institutes of Health; Natera; Robert Wood Johnson Foundation; Amgen; BeiGene; Alliance for Clinical Trials in Oncology Foundation; Jiangsu Hengrui Medicine; Prevent Cancer Foundation; Teva Pharmaceutical Industries; Massachusetts General Hospital","keywords":"Leverage (statistics); Government (linguistics); Clinical trial; Stakeholder; Pandemic; Public relations; Political science; Business; Coronavirus disease 2019 (COVID-19); Public administration; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001547364,0.0001198018,0.0002631545,0.00007094233,0.0001006465,0.000009846241,0.0001988701,0.0001430067,0.000609166],"category_scores_gemma":[0.003324195,0.00009121367,0.000104435,0.0001147756,0.00006575914,0.000002260717,0.0001823856,0.000625547,0.000001812154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006804539,"about_ca_system_score_gemma":0.0001570376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000755459,"about_ca_topic_score_gemma":0.00003777228,"domain_scores_codex":[0.9983554,0.0003111674,0.0005299365,0.0003446687,0.0002968776,0.0001619618],"domain_scores_gemma":[0.9990904,0.0002032056,0.000270532,0.0002120562,0.0001349793,0.000088789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001210153,0.0005850768,0.04161127,0.00002709959,0.000493292,0.00007334949,0.0004046892,0.0007677377,0.04548149,0.0004960412,0.7068602,0.2019896],"study_design_scores_gemma":[0.003336811,0.0003604148,0.002686793,0.00001919724,0.00006400085,0.00001788524,0.000307968,0.0006098497,0.001315013,0.00003954896,0.9911015,0.0001410276],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8384284,0.06292266,0.006025583,0.04224817,0.04285589,0.001814925,0.001555688,0.00007440698,0.004074279],"genre_scores_gemma":[0.9839739,0.002415129,0.000418428,0.00845962,0.003127877,0.0001192902,0.0009096194,0.0000225716,0.0005535551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2842413,"threshold_uncertainty_score":0.6669941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.118521832702,"score_gpt":0.4332134892440536,"score_spread":0.3146916565420536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}