{"id":"W4224249539","doi":"10.1038/s41591-022-01775-6","title":"Reimagining patient-centric cancer clinical trials: a multi-stakeholder international coalition","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Foundation Medicine; Pharmacyclics; Johns Hopkins Bloomberg School of Public Health; Weill Cornell Medical College; Genentech; Shanghai Jiao Tong University; Astellas Pharma; Eisai; Bayer HealthCare; Government of Ontario; Ontario Institute for Cancer Research; HSBC Bank USA; Baxalta; Varian Medical Systems; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; Daiichi Sankyo Europe; National Cancer Institute; Bayer; Gilead Sciences; University of Toronto; Yale University; Exelixis; Guangdong Provincial People's Hospital; Leidos; Breast Cancer Research Foundation; Sanofi; AstraZeneca; Eli Lilly and Company; Queen's University; Bloomberg L.P.; Celgene; Yale Cancer Center; Innovent Biologics; Incyte; Pfizer; National Institutes of Health; Natera; Robert Wood Johnson Foundation; Amgen; BeiGene; Alliance for Clinical Trials in Oncology Foundation; Jiangsu Hengrui Medicine; Prevent Cancer Foundation; Teva Pharmaceutical Industries; Massachusetts General Hospital","keywords":"Leverage (statistics); Government (linguistics); Clinical trial; Stakeholder; Pandemic; Public relations; Political science; Business; Coronavirus disease 2019 (COVID-19); Public administration; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4718126,0.001966265,0.002753082,0.00328598,0.01309237,0.03390145,0.01017763,0.03378106,0.009762026],"category_scores_gemma":[0.2967422,0.001885604,0.003146636,0.00278751,0.01229035,0.01508297,0.04813596,0.05459101,0.001441329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01761863,"about_ca_system_score_gemma":0.2272669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004648729,"about_ca_topic_score_gemma":0.009130653,"domain_scores_codex":[0.7834846,0.1427709,0.01071649,0.01000321,0.03064545,0.02237942],"domain_scores_gemma":[0.454801,0.2255753,0.02389156,0.02352944,0.05207132,0.2201314],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002732122,0.00441343,0.01716858,0.002297526,0.0024794,0.003353992,0.02270039,0.007050559,0.01023898,0.1910509,0.412653,0.3238612],"study_design_scores_gemma":[0.002247792,0.001744739,0.01089045,0.00262103,0.0005045368,0.0006216038,0.01151345,0.004468595,0.002340865,0.132573,0.8300371,0.0004369403],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.01337813,0.006690656,0.01471788,0.9434884,0.007396482,0.001725659,0.0001417733,0.0001662357,0.0122948],"genre_scores_gemma":[0.3066146,0.007056152,0.03644141,0.625657,0.007977255,0.004246254,0.0007247354,0.0004042143,0.01087839],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.5281874,"threshold_uncertainty_score":0.6513491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.118521832702,"score_gpt":0.4332134892440536,"score_spread":0.3146916565420536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}