{"id":"W4224249674","doi":"10.3390/cancers14081877","title":"The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"Québec Consortium for Drug Discovery; U.S. Department of Veterans Affairs","keywords":"Carboplatin; Docetaxel; Paclitaxel; Ovarian cancer; In vivo; Cancer research; Medicine; Pharmacology; Oncology; Endometrial cancer; Internal medicine; Cancer; Biology; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151293,0.0003782477,0.0002039611,0.0001567547,0.00009829464,0.0002325979,0.0001977269,0.0002903183,0.0007259546],"category_scores_gemma":[0.00004696596,0.0001276799,0.0001641235,0.0001219315,0.00013415,0.0001923043,0.0001666757,0.0003713794,0.0002666039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003081788,"about_ca_system_score_gemma":0.0001530187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003639706,"about_ca_topic_score_gemma":0.0004979486,"domain_scores_codex":[0.9999347,0.00001146734,0.000004664489,0.00001687552,0.00001867839,0.00001362124],"domain_scores_gemma":[0.9999828,0.000002132108,0.000005733899,0.000001663797,0.000002973534,0.000004642842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001189477,0.00002115554,0.00007146897,0.00005958122,0.000007430402,0.00005963716,0.000009767713,0.0001379637,0.9949415,0.0001921478,0.0001390171,0.004241281],"study_design_scores_gemma":[0.00008621396,0.0004888151,0.0008700831,0.000003906041,0.00002600425,0.0006486698,0.000007818599,0.001085173,0.9866691,0.00003395979,0.0100736,0.000006751956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722087,0.006552503,0.01390402,0.0003030358,0.0001060082,0.0002306738,0.0006754769,0.000246719,0.005772785],"genre_scores_gemma":[0.9837705,0.002923304,0.008136935,0.0001074846,0.00002153141,0.0000924327,0.000512417,0.00002778744,0.004407487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007259546,"threshold_uncertainty_score":0.002428532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478421474295775,"score_gpt":0.2551610098111171,"score_spread":0.2403767950681594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}