{"id":"W4224249674","doi":"10.3390/cancers14081877","title":"The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"Québec Consortium for Drug Discovery; U.S. Department of Veterans Affairs","keywords":"Carboplatin; Docetaxel; Paclitaxel; Ovarian cancer; In vivo; Cancer research; Medicine; Pharmacology; Oncology; Endometrial cancer; Internal medicine; Cancer; Biology; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002592288,0.0002065478,0.0001854465,0.00005324051,0.0004720725,0.00005944175,0.0003550401,0.00006390311,0.0002299474],"category_scores_gemma":[0.00005929855,0.0001704478,0.0001030987,0.0002288269,0.000164777,0.000006923589,0.0001768931,0.0002288968,0.000007691962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005065419,"about_ca_system_score_gemma":0.002013316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00379038,"about_ca_topic_score_gemma":0.002409101,"domain_scores_codex":[0.998568,0.0001288623,0.0002526013,0.0004406404,0.0002135383,0.0003963613],"domain_scores_gemma":[0.9992614,0.00005640798,0.000147245,0.0003247857,0.00006034326,0.0001497732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00302284,0.00001663325,0.003923176,0.00001993388,0.0008643007,0.00001049559,0.001183633,0.008473331,0.6994601,0.00009529109,0.1869087,0.09602151],"study_design_scores_gemma":[0.002769568,0.000443326,0.0005442681,0.00002016868,0.00005264333,0.000005752828,0.00187095,0.0006246704,0.04762772,0.0000733769,0.9454895,0.0004780411],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749673,0.020361,0.00004383209,0.001015359,0.002003189,0.0004069469,0.0002005355,0.00002432336,0.0009775091],"genre_scores_gemma":[0.9795299,0.01240302,0.000019353,0.00242618,0.0006483807,0.0002438407,0.0001202833,0.00003418106,0.004574825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7585808,"threshold_uncertainty_score":0.695066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478421474295775,"score_gpt":0.2551610098111171,"score_spread":0.2403767950681594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}