{"id":"W4224251450","doi":"10.1016/j.jtho.2022.03.014","title":"Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations","year":2022,"lang":"en","type":"review","venue":"Journal of Thoracic Oncology","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"ARC Training Centre in Lightweight Automotive Structures; Janssen Pharmaceuticals; National Institute of Environmental Health Sciences; Medical Research Council; Genentech; Andrew and Jaime Sullivan Family Foundation; National Institutes of Health; Honeywell; Aldeyra Therapeutics; BeiGene; Clovis Oncology; Astex Pharmaceuticals; Bayer Fund; National Health and Medical Research Council; AstraZeneca; Novocure; Merck Sharp and Dohme; University of Hawaiʻi Foundation; Takeda Pharmaceuticals U.S.A.; AbbVie; Medtronic; Roche; Novartis; EMD Serono; Mesothelioma Applied Research Foundation; Merck; GlaxoSmithKline; National Cancer Institute; Bayer; Maurice and Joanna Sullivan Family Foundation; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; Inventiva Pharma; Pfizer; Ariad Pharmaceuticals; Boehringer Ingelheim","keywords":"Medicine; BAP1; Germline; Mesothelioma; Germline mutation; Oncology; Internal medicine; Intensive care medicine; General surgery; Mutation; Genetics; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002479423,0.0001892678,0.00130826,0.000226498,0.00007030703,0.000003879863,0.00007693975,0.0001732675,0.0004807747],"category_scores_gemma":[0.0001402309,0.0001066551,0.0001923165,0.0001319104,0.000275808,0.00005662807,0.00009167889,0.000488167,6.01127e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001835219,"about_ca_system_score_gemma":0.0005259285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002054635,"about_ca_topic_score_gemma":0.000001781638,"domain_scores_codex":[0.9983754,0.0003019061,0.0006406854,0.0001527233,0.0004210292,0.0001082629],"domain_scores_gemma":[0.9981121,0.0007526898,0.0007430056,0.00008560361,0.00007173736,0.0002348153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006421141,0.00034395,0.009814113,0.004332618,0.0004360934,0.0004455652,0.0003920344,7.204597e-7,1.605672e-7,0.00002511272,0.00002424659,0.9835433],"study_design_scores_gemma":[0.001300081,0.003410695,0.02694524,0.004852009,0.002862726,0.003070993,0.001064307,0.000002688902,6.830468e-7,0.00004526849,0.9562766,0.000168726],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07662764,0.9223298,0.000003066229,0.0001286183,0.0000881786,0.0002491155,0.0001608978,0.000003351164,0.0004092687],"genre_scores_gemma":[0.02835289,0.9708572,0.0003552205,0.00002957058,0.0001198158,0.00001133119,0.0002008873,0.0000255806,0.00004752386],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9833745,"threshold_uncertainty_score":0.5264146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02591016594084832,"score_gpt":0.4073928890563097,"score_spread":0.3814827231154613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}