{"id":"W4224257010","doi":"10.1038/s41467-022-29722-6","title":"Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Gujarat Cancer and Research Institute; McGill University; Cancer Research Institute","keywords":"Insulin resistance; Insulin receptor; Insulin; Biology; Cell biology; Energy homeostasis; Nuclear receptor; Receptor; Endocrinology; Internal medicine; Transcription factor; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600874,0.000425319,0.0002299283,0.0002558522,0.0001269969,0.0005134649,0.0001590066,0.000238296,0.002241082],"category_scores_gemma":[0.00009357263,0.0002107397,0.0003583939,0.000131048,0.0003517465,0.0002417921,0.0003488348,0.000690781,0.0006970054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115779,"about_ca_system_score_gemma":0.0001749616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001943304,"about_ca_topic_score_gemma":0.0004348792,"domain_scores_codex":[0.9998689,0.00001958394,0.00001196765,0.00003288242,0.00003869124,0.00002794018],"domain_scores_gemma":[0.9998801,0.00001058971,0.00005285524,0.00001517387,0.00001275673,0.00002858291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001788987,0.00001872922,0.0006803593,0.0000270993,0.00001148762,0.0001418666,0.00000856085,0.00004331633,0.9966279,0.0002964668,0.00007281199,0.001892455],"study_design_scores_gemma":[0.00006202294,0.0002840677,0.03950798,0.00003144645,0.00003833211,0.00145747,0.0001092545,0.0009259334,0.9521497,0.0005640279,0.004856498,0.00001333249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816952,0.003963294,0.00745287,0.0006358275,0.0001091535,0.00002844542,0.0008231829,0.0004909182,0.004801028],"genre_scores_gemma":[0.9891583,0.001596445,0.00274836,0.0001364953,0.00001856302,0.00002588536,0.0006848559,0.00005968132,0.005571499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002241082,"threshold_uncertainty_score":0.007497132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801043208975811,"score_gpt":0.2874142733592628,"score_spread":0.2694038412695047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}