{"id":"W4224267833","doi":"10.1158/1055-9965.epi-22-0007","title":"Methylation Subtypes of Primary Prostate Cancer Predict Poor Prognosis","year":2022,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Cancer Society Research Institute; National Institutes of Health; Prostate Cancer Canada; National Cancer Institute; Fred Hutchinson Cancer Research Center","keywords":"Prostate cancer; DNA methylation; Methylation; Cancer; Prostate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003887113,0.0002208056,0.0002421234,0.0005741236,0.0002426267,0.0003910398,0.0002658906,0.0002205626,0.002187064],"category_scores_gemma":[0.001574308,0.0001029301,0.0002983894,0.000564834,0.0002292215,0.0001138411,0.0003390019,0.0003109548,0.0001795458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000468863,"about_ca_system_score_gemma":0.0006277628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01483234,"about_ca_topic_score_gemma":0.02705663,"domain_scores_codex":[0.9997815,0.00003513065,0.00001558007,0.00006281906,0.00006049921,0.0000444049],"domain_scores_gemma":[0.9992816,0.0001234861,0.0003299857,0.00006583227,0.00008742826,0.0001116555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002000252,0.00000869921,0.9913455,0.00003721379,0.0002131445,0.00003453188,0.00004507677,0.0002186267,0.002412502,0.0000318382,0.0002655157,0.00518737],"study_design_scores_gemma":[0.000005367657,0.00003424145,0.9985356,0.000007800455,0.00009976559,0.0001430236,0.00003980842,0.0002498738,0.0004576577,0.000119996,0.0003036369,0.000003202528],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995274,0.001537275,0.0004071068,0.0001744077,0.000009037694,0.00001778332,0.001495504,0.00002590381,0.001059061],"genre_scores_gemma":[0.9988208,0.0002414433,0.00013393,0.00002307594,0.000007474306,0.000004843595,0.0006335611,0.000003671743,0.0001310488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01483234,"threshold_uncertainty_score":0.02949202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0336056791907705,"score_gpt":0.3298460194443539,"score_spread":0.2962403402535834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}