{"id":"W4224272135","doi":"10.1021/acs.est.1c07945","title":"Toxicological Mechanism of Individual Susceptibility to Formaldehyde-Induced Respiratory Effects","year":2022,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Air Quality and Health Impacts","field":"Environmental Science","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Ministry of Science and Technology of the People's Republic of China; Central University Basic Research Fund of China; National Natural Science Foundation of China; Canada Research Chairs","keywords":"Genetic predisposition; Epigenetics; COPD; Biology; Genetics; Mechanism (biology); Adverse effect; Adverse Outcome Pathway; Genetic association; Medicine; Genotype; Bioinformatics; Immunology; Gene; Pharmacology; Computational biology; Single-nucleotide polymorphism; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004208196,0.0003491146,0.0003309055,0.0005104026,0.0002400942,0.0004461333,0.0003578415,0.000537637,0.001033344],"category_scores_gemma":[0.0004673336,0.0001717626,0.0005309696,0.0001693192,0.0003235645,0.0003127198,0.0005265122,0.0003850183,0.0001678492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003701603,"about_ca_system_score_gemma":0.0003103796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001648767,"about_ca_topic_score_gemma":0.001815956,"domain_scores_codex":[0.9996247,0.00006276632,0.00002400048,0.0001402942,0.00009283608,0.00005540757],"domain_scores_gemma":[0.9996686,0.00005747668,0.0001173297,0.00005925031,0.00006502888,0.0000322717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002157811,0.00006271546,0.05628768,0.0002720595,0.0002187171,0.0005814646,0.0001850953,0.001288018,0.9191443,0.001366188,0.0002539906,0.02012411],"study_design_scores_gemma":[0.00002404469,0.001439999,0.416445,0.0001004694,0.0006157092,0.004418028,0.0004295738,0.007571554,0.5549716,0.004398878,0.009495552,0.00008961899],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625274,0.005580536,0.02532177,0.0005400584,0.00005563512,0.0001082116,0.001298164,0.0002377981,0.004330414],"genre_scores_gemma":[0.9945563,0.001304512,0.002763461,0.0001246116,0.00001399206,0.0000316238,0.0002685389,0.00001219822,0.0009247818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001648767,"threshold_uncertainty_score":0.003456831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02926202510529379,"score_gpt":0.290960154991774,"score_spread":0.2616981298864802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}